TY - JOUR
T1 - The effect of tiotropium therapy on markers of elastin degradation in COPD
AU - Ma, Shuren
AU - Lin, Yong Y.
AU - Tartell, Lori
AU - Turino, Gerard M.
N1 - Funding Information:
This work was supported by funds from the James P. Mara Center for Lung Disease, the Flight Attendants Medical Research Institute, the Charles A. Mastronardi Foundation, the Ned Doyle Foundation, the Alpha One Foundation and funds from Ethel Kennedy, John Kennedy, Judith Sulzberger and the Boehringer-Ingelheim Corp. The authors express their deep appreciation to Dr. Seymour Lieberman for consultative advice.
PY - 2009/2/25
Y1 - 2009/2/25
N2 - Background: Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity. This study was undertaken to determine whether continuous therapy with the long-acting bronchodilator Tiotropium bromide (TTP) could result in reductions in D/I as measured by mass spectrometry in plasma, urine and sputum.Methods: Twelve not currently smoking patients with chronic obstructive pulmonary disease (COPD), never on TTP, were selected for study. Levels of D/I, along with measurements of FVC, FEV1 and FEV1/FVC. were determined before starting TTP daily, and then one and two months after.Results: D/I decreased in plasma (10 of 12 patients), in sputum all (12 of 12), and in the percentage of free D/I in urine (10 of 12). Most patients showed slight increases in FVC and FEV1 percent predicted over two months.Conclusion: The results are consistent with an effect of prolonged bronchodilitation by anti-cholinergic blockade to also result in reduced lung elastin degradation.
AB - Background: Desmosine and Isodesmosine (D/I) are cross-linking amino acids which are present only in mature elastin. Changes in their concentration in body fluids indicate changes in elastin degradation and can be a reflection of tissue elastase activity. This study was undertaken to determine whether continuous therapy with the long-acting bronchodilator Tiotropium bromide (TTP) could result in reductions in D/I as measured by mass spectrometry in plasma, urine and sputum.Methods: Twelve not currently smoking patients with chronic obstructive pulmonary disease (COPD), never on TTP, were selected for study. Levels of D/I, along with measurements of FVC, FEV1 and FEV1/FVC. were determined before starting TTP daily, and then one and two months after.Results: D/I decreased in plasma (10 of 12 patients), in sputum all (12 of 12), and in the percentage of free D/I in urine (10 of 12). Most patients showed slight increases in FVC and FEV1 percent predicted over two months.Conclusion: The results are consistent with an effect of prolonged bronchodilitation by anti-cholinergic blockade to also result in reduced lung elastin degradation.
UR - http://www.scopus.com/inward/record.url?scp=70249128358&partnerID=8YFLogxK
U2 - 10.1186/1465-9921-10-12
DO - 10.1186/1465-9921-10-12
M3 - Article
C2 - 19243601
AN - SCOPUS:70249128358
SN - 1465-9921
VL - 10
JO - Respiratory Research
JF - Respiratory Research
M1 - 12
ER -