The effect of target-gas purity on the chemical form of F-18 during 18F-F 2 production using the neon/fluorine target

G. T. Bida, R. L. Ehrenkaufer, A. P. Wolf, J. S. Fowler, R. R. MacGregor, T. J. Ruth

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42 Scopus citations

Abstract

Irradiation of gas mixtures of F 2/Ne ( 20Ne→d,α 18F) which contained percent levels (>0.1%) of N 2, CO 2, or CF 4 resulted in the production of unacceptable levels of F-18-labeled NF 3 and CF 4 at the expense of 18F-F 2. Analytical gas chromatographic methods have been devised to determine contaminant levels in the target gas as well as in the products arising from them. Commercial mixtures of 1% F 2/Ne, pure F 2, and neon have been analyzed for contaminants (N 2, O 2, CO, CO 2, and CF 4) and found to vary widely in the levels of these impurities from batch to batch. The N 2 levels in the 1% F 2/Ne mixtures varied from 0.039 to 0.49%, and the CO 2 levels from 0.028 to 0.13%. No detectable impurities were found in the neon (Research Purity), but F 2 was found to contain ~11% CF 4. Reproducibly high yields of 18F-F 2 are obtained if the levels of N 2, CO 2, and CF 4 in the final target gas mixture are <0.01% and carrier F 2 is ~0.1%. Hydrocarbons and CO were not detected in our gas mixtures, but would also be expected to decrease yields of 18F-F 2.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalJournal of Nuclear Medicine
Volume21
Issue number8
StatePublished - 1980

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