The effect of storage on the nucleic acid content and virulence of mouse ascites tumor

Eva Klein; N. B. Kurnick; G. Klein

doi:10.1016/0014-4827(50)90053-X

The effect of storage on the nucleic acid content and virulence of mouse ascites tumor

Eva Klein
, N. B. Kurnick
, G. Klein

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of storage for 9 days in the cold on the nucleic acid content and virulence of ascites tumor cells was studied by chemical and U.V. methods, It was found that storage was accompanied by considerable loss of cellular RNA but not of DNA. Correlated with the loss of RNA is a reduction in virulence. Evidence is presented to indicate that the cells survive the storage period. The high constant DNA content as compared to other somatic cells may possibly be interpreted as evidence of polyploidy in ascites tumor cells.

Original language	English
Pages (from-to)	127-134
Number of pages	8
Journal	Experimental Cell Research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0014-4827(50)90053-X
State	Published - 1950
Externally published	Yes

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title = "The effect of storage on the nucleic acid content and virulence of mouse ascites tumor",

abstract = "The effect of storage for 9 days in the cold on the nucleic acid content and virulence of ascites tumor cells was studied by chemical and U.V. methods, It was found that storage was accompanied by considerable loss of cellular RNA but not of DNA. Correlated with the loss of RNA is a reduction in virulence. Evidence is presented to indicate that the cells survive the storage period. The high constant DNA content as compared to other somatic cells may possibly be interpreted as evidence of polyploidy in ascites tumor cells.",

author = "Eva Klein and Kurnick, \{N. B.\} and G. Klein",

note = "Funding Information: 1 This work WBSd one in part (N. 13. Kurnick) under a fellowship of the American Cancer Society recommended by the National Research Council, Committee on Growth.",

year = "1950",

doi = "10.1016/0014-4827(50)90053-X",

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journal = "Experimental Cell Research",

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T1 - The effect of storage on the nucleic acid content and virulence of mouse ascites tumor

AU - Klein, Eva

AU - Kurnick, N. B.

AU - Klein, G.

N1 - Funding Information: 1 This work WBSd one in part (N. 13. Kurnick) under a fellowship of the American Cancer Society recommended by the National Research Council, Committee on Growth.

PY - 1950

Y1 - 1950

N2 - The effect of storage for 9 days in the cold on the nucleic acid content and virulence of ascites tumor cells was studied by chemical and U.V. methods, It was found that storage was accompanied by considerable loss of cellular RNA but not of DNA. Correlated with the loss of RNA is a reduction in virulence. Evidence is presented to indicate that the cells survive the storage period. The high constant DNA content as compared to other somatic cells may possibly be interpreted as evidence of polyploidy in ascites tumor cells.

AB - The effect of storage for 9 days in the cold on the nucleic acid content and virulence of ascites tumor cells was studied by chemical and U.V. methods, It was found that storage was accompanied by considerable loss of cellular RNA but not of DNA. Correlated with the loss of RNA is a reduction in virulence. Evidence is presented to indicate that the cells survive the storage period. The high constant DNA content as compared to other somatic cells may possibly be interpreted as evidence of polyploidy in ascites tumor cells.

UR - https://www.scopus.com/pages/publications/50349104764

U2 - 10.1016/0014-4827(50)90053-X

DO - 10.1016/0014-4827(50)90053-X

M3 - Article

AN - SCOPUS:50349104764

SN - 0014-4827

VL - 1

SP - 127

EP - 134

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 1

ER -

The effect of storage on the nucleic acid content and virulence of mouse ascites tumor

Abstract

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