The effect of sodium salicylate on dibutyryl cyclic amp fever in the conscious rabbit

G. H. Willies, C. J. Woolf, C. Rosendorff

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Bilateral injections of dibutyryl cyclic adenosine-3',5'-monophosphate (dibutyryl cyclic AMP), in a dose of 1 μg per injection, into the anterior hypothalamus of the conscious New Zealand White rabbit, produced a fever (0.8 ± 0.1 °C) with a short latency of onset (3.8 ± 1.5 min). Prior administration of a bolus of sodium salicylate followed by a constant infusion failed to reduce the dibutyryl cyclic AMP-induced hyperthermia. This is consistent with previously reported data supporting a role for cyclic AMP in the pathogenesis of PGE1 fevers.

Original languageEnglish
Pages (from-to)9-10
Number of pages2
JournalNeuropharmacology
Volume15
Issue number1
DOIs
StatePublished - Jan 1976
Externally publishedYes

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