The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study

Remko Van Lutterveld; Sanne Koops; Dennis J.L.G. Schutter; Ellen Geertsema; Cornelis J. Stam; René S. Kahn; Iris E.C. Sommer

doi:10.1016/j.schres.2012.01.010

The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study

Remko Van Lutterveld, Sanne Koops, Dennis J.L.G. Schutter, Ellen Geertsema, Cornelis J. Stam, René S. Kahn, Iris E.C. Sommer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objctive: Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most large randomized controlled trials failed to demonstrate a superior effect of rTMS treatment as compared to sham. Previous studies applied daily rTMS sessions for one or more weeks to summate its effects. However, the effect of a single rTMS treatment on AVH-severity has never been studied, making it unclear if there is an initial effect that could be increased by repeated treatment. Methods: In three separate sessions, twenty-four patients with a psychotic disorder received 1-Hz rTMS to the left temporoparietal cortex, its right-sided homologue or a centro-occipital control site. Severity of AVH was assessed before and after each rTMS session and resting-state EEGs were recorded to investigate the neuronal effects of rTMS. Results: Stimulation of the temporoparietal cortices was not more effective in reducing AVH-severity than control-site stimulation. In addition, EEG-related power and connectivity measures were not affected differently across stimulation sites and changes in neuronal activity did not correlate with changes in AVH-severity. Conclusions: These results may suggest a placebo effect of a single session of 1-Hz rTMS treatment on AVH-severity.

Original language	English
Pages (from-to)	174-179
Number of pages	6
Journal	Schizophrenia Research
Volume	137
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2012.01.010
State	Published - May 2012
Externally published	Yes

Keywords

EEG
Graph analysis
Hallucinations
Placebo
Schizophrenia
TMS

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10.1016/j.schres.2012.01.010

Cite this

@article{fe98fed587ca4466a5342c31daff5f5b,

title = "The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study",

abstract = "Objctive: Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most large randomized controlled trials failed to demonstrate a superior effect of rTMS treatment as compared to sham. Previous studies applied daily rTMS sessions for one or more weeks to summate its effects. However, the effect of a single rTMS treatment on AVH-severity has never been studied, making it unclear if there is an initial effect that could be increased by repeated treatment. Methods: In three separate sessions, twenty-four patients with a psychotic disorder received 1-Hz rTMS to the left temporoparietal cortex, its right-sided homologue or a centro-occipital control site. Severity of AVH was assessed before and after each rTMS session and resting-state EEGs were recorded to investigate the neuronal effects of rTMS. Results: Stimulation of the temporoparietal cortices was not more effective in reducing AVH-severity than control-site stimulation. In addition, EEG-related power and connectivity measures were not affected differently across stimulation sites and changes in neuronal activity did not correlate with changes in AVH-severity. Conclusions: These results may suggest a placebo effect of a single session of 1-Hz rTMS treatment on AVH-severity.",

keywords = "EEG, Graph analysis, Hallucinations, Placebo, Schizophrenia, TMS",

author = "\{Van Lutterveld\}, Remko and Sanne Koops and Schutter, \{Dennis J.L.G.\} and Ellen Geertsema and Stam, \{Cornelis J.\} and Kahn, \{Ren{\'e} S.\} and Sommer, \{Iris E.C.\}",

note = "Funding Information: Funding for this study was provided by the Dutch Science Organization (Nederlandse Wetenschappelijke Organisatie NWO), Innovation Impulse (VIDI), nr. 017.106.301 ",

year = "2012",

month = may,

doi = "10.1016/j.schres.2012.01.010",

language = "English",

volume = "137",

pages = "174--179",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1-3",

}

TY - JOUR

T1 - The effect of rTMS on auditory hallucinations

T2 - Clues from an EEG-rTMS study

AU - Van Lutterveld, Remko

AU - Koops, Sanne

AU - Schutter, Dennis J.L.G.

AU - Geertsema, Ellen

AU - Stam, Cornelis J.

AU - Kahn, René S.

AU - Sommer, Iris E.C.

N1 - Funding Information: Funding for this study was provided by the Dutch Science Organization (Nederlandse Wetenschappelijke Organisatie NWO), Innovation Impulse (VIDI), nr. 017.106.301

PY - 2012/5

Y1 - 2012/5

N2 - Objctive: Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most large randomized controlled trials failed to demonstrate a superior effect of rTMS treatment as compared to sham. Previous studies applied daily rTMS sessions for one or more weeks to summate its effects. However, the effect of a single rTMS treatment on AVH-severity has never been studied, making it unclear if there is an initial effect that could be increased by repeated treatment. Methods: In three separate sessions, twenty-four patients with a psychotic disorder received 1-Hz rTMS to the left temporoparietal cortex, its right-sided homologue or a centro-occipital control site. Severity of AVH was assessed before and after each rTMS session and resting-state EEGs were recorded to investigate the neuronal effects of rTMS. Results: Stimulation of the temporoparietal cortices was not more effective in reducing AVH-severity than control-site stimulation. In addition, EEG-related power and connectivity measures were not affected differently across stimulation sites and changes in neuronal activity did not correlate with changes in AVH-severity. Conclusions: These results may suggest a placebo effect of a single session of 1-Hz rTMS treatment on AVH-severity.

AB - Objctive: Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most large randomized controlled trials failed to demonstrate a superior effect of rTMS treatment as compared to sham. Previous studies applied daily rTMS sessions for one or more weeks to summate its effects. However, the effect of a single rTMS treatment on AVH-severity has never been studied, making it unclear if there is an initial effect that could be increased by repeated treatment. Methods: In three separate sessions, twenty-four patients with a psychotic disorder received 1-Hz rTMS to the left temporoparietal cortex, its right-sided homologue or a centro-occipital control site. Severity of AVH was assessed before and after each rTMS session and resting-state EEGs were recorded to investigate the neuronal effects of rTMS. Results: Stimulation of the temporoparietal cortices was not more effective in reducing AVH-severity than control-site stimulation. In addition, EEG-related power and connectivity measures were not affected differently across stimulation sites and changes in neuronal activity did not correlate with changes in AVH-severity. Conclusions: These results may suggest a placebo effect of a single session of 1-Hz rTMS treatment on AVH-severity.

KW - EEG

KW - Graph analysis

KW - Hallucinations

KW - Placebo

KW - Schizophrenia

KW - TMS

UR - https://www.scopus.com/pages/publications/84860839428

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DO - 10.1016/j.schres.2012.01.010

M3 - Article

C2 - 22289867

AN - SCOPUS:84860839428

SN - 0920-9964

VL - 137

SP - 174

EP - 179

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study

Abstract

Keywords

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