The effect of repository heparin upon lipoprotein pat terns in human beings

In this study the marked effect of repository heparin upon the lipoprotein pattern of human beings has been demonstrated. It thus constitutes a confirmation of the initial observation of Graham et al. (7) in this regard. We have observed that the most pronounced effect is upon the lipoproteins in the Sf 35-100 range, wherein their concentration four hours after the injection of the repository heparin is reduced by an average of 80 per cent. Lipoproteins of lower Sf rates are affected less consistently. There appears to be little or no difference in response between doses of 200 mg to 400 mg of repository heparin. The duration of the effect was found to be 24 hours on the average. However, several important exceptions to this were found in which marked lowering of the concentration of the Sf 35-100 group persisted for 72 hours after heparin administration.