TY - JOUR
T1 - The Effect of Propranolol on Uncontrolled Rage Outbursts in Children and Adolescents with Organic Brain Dysfunction
AU - WILLIAMS, DANIEL T.
AU - MEHL, RAY
AU - YUDOFSKY, STUART
AU - ADAMS, DAVID
AU - ROSEMAN, BRUCE
N1 - Funding Information:
Dr. Williams is Assistant Professor ofClinical Psychiatry and Director of the Pediatric Neuropsychiatry Service, Dr. Mehl is Senior Fellow in Pediatric Neurology, Dr. Yudofsky is Assistant Professor of Clinical Psychiatry and Director of the Neuropsychiatric Diagnostic and Treatment Center, Dr. Adams is Assistant Clinical Professor ofNeurology, and Dr. Roseman is Assistant in Clinical Neurology, all at the Columbia-Presbyterian Medical Center. The authors are grateful to Dr. Donald Ross and Mrs. Henny Wolland for statistical guidance, to Dr. Arnold Gold and Dr. Ri chard Masland for clinical advice, and Dr. David Shaffer, Dr. Rachel Gittelman, and Dr. Donald Klein for their editorial suggestions. We are also grateful for financial support provided by the Wodecroft Foundation. This study was also supp orted in part by an NIMH grant MHCRC-N.Y.S. Psychiatric Institute MH 30906. Reprints may be requested from Dr. Williams at 622 West 168th Street, New York, NY 10032 This paper was presented at the 1980 annual meeting of the American Academy of Child Psychiatry, Chicago. 0002-7138/82/2102-0129 $02.00/0. Copyright © 1982 by the American Academy of Child Psychiatry.
PY - 1982
Y1 - 1982
N2 - This paper reviews our experience using propranolol, a β-adrenergic blocking agent, in 30 patients who had uncontrolled rage outbursts over a period of at least 6 months, starting in childhood or adolescence. All of these patients had concomitant organic brain dysfunction, ranging from minimal brain dysfunction to severe, uncontrolled seizures. All patients had prior unsuccessful medication treatment, consisting of trials on stimulants, neuroleptics, anticonvulsants, or combinations of these. The majority of patients also had prior psychotherapeutic intervention, all without success. In our retrospective study, more than 75% of the patients demonstrated moderate to marked improvement in control of rage outbursts and aggressive behavior. These data point to the merits of a controlled prospective study of the use of propranolol in treating neurologically impaired children and adolescents with uncontrolled rage outbursts. Journal of the American Academy of Child Psychiatry, 21, 2:129–135, 1982.
AB - This paper reviews our experience using propranolol, a β-adrenergic blocking agent, in 30 patients who had uncontrolled rage outbursts over a period of at least 6 months, starting in childhood or adolescence. All of these patients had concomitant organic brain dysfunction, ranging from minimal brain dysfunction to severe, uncontrolled seizures. All patients had prior unsuccessful medication treatment, consisting of trials on stimulants, neuroleptics, anticonvulsants, or combinations of these. The majority of patients also had prior psychotherapeutic intervention, all without success. In our retrospective study, more than 75% of the patients demonstrated moderate to marked improvement in control of rage outbursts and aggressive behavior. These data point to the merits of a controlled prospective study of the use of propranolol in treating neurologically impaired children and adolescents with uncontrolled rage outbursts. Journal of the American Academy of Child Psychiatry, 21, 2:129–135, 1982.
UR - http://www.scopus.com/inward/record.url?scp=0020072087&partnerID=8YFLogxK
U2 - 10.1016/S0002-7138(09)60911-0
DO - 10.1016/S0002-7138(09)60911-0
M3 - Article
C2 - 7069079
AN - SCOPUS:0020072087
SN - 0002-7138
VL - 21
SP - 129
EP - 135
JO - Journal of the American Academy of Child Psychiatry
JF - Journal of the American Academy of Child Psychiatry
IS - 2
ER -