The effect of plasmapheresis on the serum activity level of dalteparin: A case report

M. Sabloff, P. S. Wells

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The effect of plasmapheresis on the anticoagulant properties of the low molecular weight heparins has never been studied. We had the opportunity to study this effect in a woman who was receiving dalteparin for the treatment of a pulmonary embolus and required plasmapheresis. Over the course of 8 days, five courses of plasmapheresis were performed. Anti-Xa activity was measured pre- and post-dalteparin administration both during and between the first three courses of plasmapheresis. Comparing the rate of change between pairs of anti-Xa activity, the absorption rate was found to have decreased by over 50%. The decay rate, as compared with a historical control, was found to have increased by over 480%. These results suggest that the level of anticoagulation of dalteparin, as monitored through an anti-Xa assay, is reduced by plasmapheresis. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume11
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Agglutinin
  • Antithrombin III
  • Cardiopulmonary bypass
  • Cold
  • Low molecular weight heparin
  • Pharmacokinetics
  • Plasmapheresis
  • Pulmonary embolism
  • Therapeutics

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