The effect of nonporous PTFE-covered stents on intimal hyperplasia following balloon arterial injury in minipigs

J. G. Yuan, T. Ohki, M. L. Marin, R. T. Quintos, D. L. Krohn, J. J. Beitler, F. J. Veith

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16 Scopus citations


Purpose: To report an experimental study investigating the ability of nonporous polytetrafluoroethylene (PTFE) covering on a metallic stent to retard the development of neointimal hyperplasia (NIH). Methods: Three groups of Hanford miniature swine underwent standardized balloon injury to both external lilac arteries. Group I animals (control) received balloon injuries only. Group II had the site of balloon injury supported by a properly sized, balloon-expandable Palmaz stent placed directly over the injury site. Group III animals received a Palmaz stent covered with PTFE graft. All animals underwent arteriography immediately after intervention and again prior to sacrifice and specimen harvest at 4 weeks. The specimens were examined grossly and histologically at the proximal, middle, and distal segments for NIH development. Results: Uncovered stents developed significantly more NIH (p < 0.0001) and greater luminal narrowing (p < 0.001) than the controls. PTFE-covered stents (group III) exhibited less NIH (p < 0.001) and luminal reduction (p < 0.01) than bare stents (group II) at the middle portion of the stent-graft, but the PTFE cover had no effect on NIH and lumen reduction at the proximal or distal ends of the prosthesis. Conclusions: PTFE-covered stents retarded NIH at 4 weeks, but only at the midportion of the devices; the covering did not prevent neointimal pannus ingrowth at the proximal and distal ends.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalJournal of Endovascular Surgery
Issue number4
StatePublished - 1998
Externally publishedYes


  • Balloon-expandable stents
  • External iliac artery
  • Palmaz stent
  • Restenosis


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