The effect of MK-927, a topical carbonic anhydrase inhibitor, on IOP in glaucomatous monkeys

R. F. Wang; Janet B. Serle; Steven M. Podos; M. F. Sugrue

doi:10.3109/02713689008995202

The effect of MK-927, a topical carbonic anhydrase inhibitor, on IOP in glaucomatous monkeys

R. F. Wang, Janet B. Serle, Steven M. Podos, M. F. Sugrue

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

MK-927 is a water soluble, potent inhibitor of human carbonic anhydrase (CA) II in vitro. Topical administration of MK-927 reduces intraocular pressure (IOP) in rabbits. Elevated IOP was produced in cynomolcjus monkey eyes by argon laser photocoagulation of the trabecular meshwork. IOP was measured at 0 hr, 0.5 hr and hourly for 8 hrs in 8 eyes for two baseline days, one day on vehicle and five days of therapy with 2% MK-927 b.i.d., after initial single-dose trials of various concentrations. IOP was not significantly different comparing baseline and vehicle treated days. Significant (p < 0.05) reductions of IOP occurred for five days lasting at least 8 hrs after each dosing. At 3 hrs after treatment with vehicle the IOP was 31.6 ± 3.4 (SE) mm Hg. Maximum reduction of IOP occurred at 3 hrs after application of MK-927, the IOP decreasing from day 1 (19.9 ± 1.0 mm Hg) to day 5 (16.5 ± 1.6 mm Hg). MK-927 appear-s to have great clinical potential.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Current Eye Research
Volume	9
Issue number	2
DOIs	https://doi.org/10.3109/02713689008995202
State	Published - 1990

Access to Document

10.3109/02713689008995202

Cite this

@article{4f3cf24370eb4a969695048ff8a6ce78,

title = "The effect of MK-927, a topical carbonic anhydrase inhibitor, on IOP in glaucomatous monkeys",

abstract = "MK-927 is a water soluble, potent inhibitor of human carbonic anhydrase (CA) II in vitro. Topical administration of MK-927 reduces intraocular pressure (IOP) in rabbits. Elevated IOP was produced in cynomolcjus monkey eyes by argon laser photocoagulation of the trabecular meshwork. IOP was measured at 0 hr, 0.5 hr and hourly for 8 hrs in 8 eyes for two baseline days, one day on vehicle and five days of therapy with 2% MK-927 b.i.d., after initial single-dose trials of various concentrations. IOP was not significantly different comparing baseline and vehicle treated days. Significant (p < 0.05) reductions of IOP occurred for five days lasting at least 8 hrs after each dosing. At 3 hrs after treatment with vehicle the IOP was 31.6 ± 3.4 (SE) mm Hg. Maximum reduction of IOP occurred at 3 hrs after application of MK-927, the IOP decreasing from day 1 (19.9 ± 1.0 mm Hg) to day 5 (16.5 ± 1.6 mm Hg). MK-927 appear-s to have great clinical potential.",

author = "Wang, {R. F.} and Serle, {Janet B.} and Podos, {Steven M.} and Sugrue, {M. F.}",

note = "Funding Information: supported in part by grants f m Merck Sharp L Dohme; EY 05852, EY 01867 frcan the National Eye Institute, an unrestricted grant frm Research to Prevent Blindness , Inc., New York, and a fellm-ship (R. F. Wang) supported by the Chah d Rose Rrairnan Research Fund of The Glaucma Foundation.",

year = "1990",

doi = "10.3109/02713689008995202",

language = "English",

volume = "9",

pages = "163--168",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - The effect of MK-927, a topical carbonic anhydrase inhibitor, on IOP in glaucomatous monkeys

AU - Wang, R. F.

AU - Serle, Janet B.

AU - Podos, Steven M.

AU - Sugrue, M. F.

N1 - Funding Information: supported in part by grants f m Merck Sharp L Dohme; EY 05852, EY 01867 frcan the National Eye Institute, an unrestricted grant frm Research to Prevent Blindness , Inc., New York, and a fellm-ship (R. F. Wang) supported by the Chah d Rose Rrairnan Research Fund of The Glaucma Foundation.

PY - 1990

Y1 - 1990

N2 - MK-927 is a water soluble, potent inhibitor of human carbonic anhydrase (CA) II in vitro. Topical administration of MK-927 reduces intraocular pressure (IOP) in rabbits. Elevated IOP was produced in cynomolcjus monkey eyes by argon laser photocoagulation of the trabecular meshwork. IOP was measured at 0 hr, 0.5 hr and hourly for 8 hrs in 8 eyes for two baseline days, one day on vehicle and five days of therapy with 2% MK-927 b.i.d., after initial single-dose trials of various concentrations. IOP was not significantly different comparing baseline and vehicle treated days. Significant (p < 0.05) reductions of IOP occurred for five days lasting at least 8 hrs after each dosing. At 3 hrs after treatment with vehicle the IOP was 31.6 ± 3.4 (SE) mm Hg. Maximum reduction of IOP occurred at 3 hrs after application of MK-927, the IOP decreasing from day 1 (19.9 ± 1.0 mm Hg) to day 5 (16.5 ± 1.6 mm Hg). MK-927 appear-s to have great clinical potential.

AB - MK-927 is a water soluble, potent inhibitor of human carbonic anhydrase (CA) II in vitro. Topical administration of MK-927 reduces intraocular pressure (IOP) in rabbits. Elevated IOP was produced in cynomolcjus monkey eyes by argon laser photocoagulation of the trabecular meshwork. IOP was measured at 0 hr, 0.5 hr and hourly for 8 hrs in 8 eyes for two baseline days, one day on vehicle and five days of therapy with 2% MK-927 b.i.d., after initial single-dose trials of various concentrations. IOP was not significantly different comparing baseline and vehicle treated days. Significant (p < 0.05) reductions of IOP occurred for five days lasting at least 8 hrs after each dosing. At 3 hrs after treatment with vehicle the IOP was 31.6 ± 3.4 (SE) mm Hg. Maximum reduction of IOP occurred at 3 hrs after application of MK-927, the IOP decreasing from day 1 (19.9 ± 1.0 mm Hg) to day 5 (16.5 ± 1.6 mm Hg). MK-927 appear-s to have great clinical potential.

UR - http://www.scopus.com/inward/record.url?scp=0025256966&partnerID=8YFLogxK

U2 - 10.3109/02713689008995202

DO - 10.3109/02713689008995202

M3 - Article

C2 - 2335112

AN - SCOPUS:0025256966

SN - 0271-3683

VL - 9

SP - 163

EP - 168

JO - Current Eye Research

JF - Current Eye Research

IS - 2

ER -

The effect of MK-927, a topical carbonic anhydrase inhibitor, on IOP in glaucomatous monkeys

Abstract

Access to Document

Fingerprint

Cite this