TY - JOUR
T1 - The effect of liraglutide on endothelial function in patients with type 2 diabetes
AU - Nandy, Debashis
AU - Johnson, Christopher
AU - Basu, Rita
AU - Joyner, Michael
AU - Brett, Jason
AU - Svendsen, Claus Bo
AU - Basu, Ananda
N1 - Publisher Copyright:
© 2014 The Author(s).
PY - 2014/11/27
Y1 - 2014/11/27
N2 - This single-centre, 12-week, double-blind, placebo-controlled trial assessed how the human glucagon-like-peptide 1 analogue liraglutide impacted endothelial function in adult patients (n = 49) with type 2 diabetes and no overt cardiovascular disease. Patients were randomized to liraglutide, placebo or glimepiride. At baseline and Week 12, venous occlusion plethysmography was used to measure forearm blood flow (FBF) in response to acetylcholine (ACh) and sodium nitroprusside (SNP) before and after l-NG-monomethyl arginine (L-NMMA) infusion. At Week 12, ACh-mediated FBF increased with liraglutide and decreased with placebo; however, the between-treatment difference was not significant (p = 0.055). Inhibition of ACh-mediated FBF after L-NMMA infusion increased with liraglutide and decreased with placebo; this between-treatment difference was also not significant (p = 0.149). No change in FBF was observed with SNP. Liraglutide did not significantly impact endothelium-dependent vasodilation after 12 weeks; however, additional investigations looking at the effect of liraglutide on endothelial function in alternative vasculature and during the postprandial period are warranted.
AB - This single-centre, 12-week, double-blind, placebo-controlled trial assessed how the human glucagon-like-peptide 1 analogue liraglutide impacted endothelial function in adult patients (n = 49) with type 2 diabetes and no overt cardiovascular disease. Patients were randomized to liraglutide, placebo or glimepiride. At baseline and Week 12, venous occlusion plethysmography was used to measure forearm blood flow (FBF) in response to acetylcholine (ACh) and sodium nitroprusside (SNP) before and after l-NG-monomethyl arginine (L-NMMA) infusion. At Week 12, ACh-mediated FBF increased with liraglutide and decreased with placebo; however, the between-treatment difference was not significant (p = 0.055). Inhibition of ACh-mediated FBF after L-NMMA infusion increased with liraglutide and decreased with placebo; this between-treatment difference was also not significant (p = 0.149). No change in FBF was observed with SNP. Liraglutide did not significantly impact endothelium-dependent vasodilation after 12 weeks; however, additional investigations looking at the effect of liraglutide on endothelial function in alternative vasculature and during the postprandial period are warranted.
KW - Glucagon-like peptide-1
KW - endothelial function
KW - liraglutide
UR - http://www.scopus.com/inward/record.url?scp=84912035416&partnerID=8YFLogxK
U2 - 10.1177/1479164114547358
DO - 10.1177/1479164114547358
M3 - Article
C2 - 25212693
AN - SCOPUS:84912035416
SN - 1479-1641
VL - 11
SP - 419
EP - 430
JO - Diabetes and Vascular Disease Research
JF - Diabetes and Vascular Disease Research
IS - 6
ER -