The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey

A. Antal; I. Bodis-Wollner; M. F. Ghilardi; A. Glover; L. Mylin; J. Toldi

doi:10.1016/0013-4694(93)90108-8

The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey

A. Antal
, I. Bodis-Wollner
, M. F. Ghilardi
, A. Glover
, L. Mylin
, J. Toldi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a "go"/"no-go" visual "oddball" discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0° or 45°). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5 ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.

Original language	English
Pages (from-to)	268-274
Number of pages	7
Journal	Electroencephalography and Clinical Neurophysiology
Volume	86
Issue number	4
DOIs	https://doi.org/10.1016/0013-4694(93)90108-8
State	Published - Apr 1993
Externally published	Yes

Keywords

Cholinergic mechanism
Cognition
Event-related potentials
Levo-acetyl-carnitine (LAC)
Neurotransmitter
P300
Primates

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10.1016/0013-4694(93)90108-8

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title = "The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey",

abstract = "We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a {"}go{"}/{"}no-go{"} visual {"}oddball{"} discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0° or 45°). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5 ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.",

keywords = "Cholinergic mechanism, Cognition, Event-related potentials, Levo-acetyl-carnitine (LAC), Neurotransmitter, P300, Primates",

author = "A. Antal and I. Bodis-Wollner and Ghilardi, \{M. F.\} and A. Glover and L. Mylin and J. Toldi",

year = "1993",

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doi = "10.1016/0013-4694(93)90108-8",

language = "English",

volume = "86",

pages = "268--274",

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T1 - The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey

AU - Antal, A.

AU - Bodis-Wollner, I.

AU - Ghilardi, M. F.

AU - Glover, A.

AU - Mylin, L.

AU - Toldi, J.

PY - 1993/4

Y1 - 1993/4

N2 - We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a "go"/"no-go" visual "oddball" discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0° or 45°). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5 ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.

AB - We studied acute and chronic effects of levo-acetyl-carnitine (LAC) on event-related potentials (ERPs) in 3 monkeys trained in a "go"/"no-go" visual "oddball" discrimination task. The stimuli were 2.5 cpd sinusoidal gratings differing in their respective orientation only (0° or 45°). Each monkey was trained to release a lever during a prespecified time window. Target stimulus presentation probabilities were between 0.25 and 0.5 ERPs had comparable mean latencies and amplitudes in all monkeys. Primary evoked potentials recorded to either the target or non-target stimulus did not change significantly as a result of LAC treatment. On the other hand, P300 latency decreased following LAC administration, with a maximum occurring in 15-20 min. The major effects of LAC were consistent within each animal and for all three of them.

KW - Cholinergic mechanism

KW - Cognition

KW - Event-related potentials

KW - Levo-acetyl-carnitine (LAC)

KW - Neurotransmitter

KW - P300

KW - Primates

UR - https://www.scopus.com/pages/publications/0027538544

U2 - 10.1016/0013-4694(93)90108-8

DO - 10.1016/0013-4694(93)90108-8

M3 - Article

C2 - 7682930

AN - SCOPUS:0027538544

SN - 0013-4694

VL - 86

SP - 268

EP - 274

JO - Electroencephalography and Clinical Neurophysiology

JF - Electroencephalography and Clinical Neurophysiology

IS - 4

ER -

The effect of levo-acetyl-carnitine on visual cognitive evoked potentials in the behaving monkey

Abstract

Keywords

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