The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Stephen A. Klassen; Jonathon W. Senefeld; Patrick W. Johnson; Rickey E. Carter; Chad C. Wiggins; Shmuel Shoham; Brenda J. Grossman; Jeffrey P. Henderson; James Musser; Eric Salazar; William R. Hartman; Nicole M. Bouvier; Sean T.H. Liu; Liise anne Pirofski; Sarah E. Baker; Noud van Helmond; R. Scott Wright; De Lisa Fairweather; Katelyn A. Bruno; Zhen Wang; Nigel S. Paneth; Arturo Casadevall; Michael J. Joyner

doi:10.1016/j.mayocp.2021.02.008

The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Stephen A. Klassen
, Jonathon W. Senefeld
, Patrick W. Johnson
, Rickey E. Carter
, Chad C. Wiggins
, Shmuel Shoham
, Brenda J. Grossman
, Jeffrey P. Henderson
, James Musser
, Eric Salazar
, William R. Hartman
, Nicole M. Bouvier
, Sean T.H. Liu
, Liise anne Pirofski
, Sarah E. Baker
, Noud van Helmond
, R. Scott Wright
, De Lisa Fairweather
, Katelyn A. Bruno
, Zhen Wang

Nigel S. Paneth, Arturo Casadevall, Michael J. Joyner

Research output: Contribution to journal › Review article › peer-review

120 Scopus citations

Abstract

To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

Original language	English
Pages (from-to)	1262-1275
Number of pages	14
Journal	Mayo Clinic Proceedings
Volume	96
Issue number	5
DOIs	https://doi.org/10.1016/j.mayocp.2021.02.008
State	Published - May 2021

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10.1016/j.mayocp.2021.02.008

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Klassen, S. A., Senefeld, J. W., Johnson, P. W., Carter, R. E., Wiggins, C. C., Shoham, S., Grossman, B. J., Henderson, J. P., Musser, J., Salazar, E., Hartman, W. R., Bouvier, N. M., Liu, S. T. H., Pirofski, L. A., Baker, S. E., van Helmond, N., Wright, R. S., Fairweather, D. L., Bruno, K. A., ... Joyner, M. J. (2021). The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis. Mayo Clinic Proceedings, 96(5), 1262-1275. https://doi.org/10.1016/j.mayocp.2021.02.008

@article{321422f9ac8341dca072fc73ee013a9b,

title = "The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis",

abstract = "To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.",

author = "Klassen, \{Stephen A.\} and Senefeld, \{Jonathon W.\} and Johnson, \{Patrick W.\} and Carter, \{Rickey E.\} and Wiggins, \{Chad C.\} and Shmuel Shoham and Grossman, \{Brenda J.\} and Henderson, \{Jeffrey P.\} and James Musser and Eric Salazar and Hartman, \{William R.\} and Bouvier, \{Nicole M.\} and Liu, \{Sean T.H.\} and Pirofski, \{Liise anne\} and Baker, \{Sarah E.\} and \{van Helmond\}, Noud and Wright, \{R. Scott\} and Fairweather, \{De Lisa\} and Bruno, \{Katelyn A.\} and Zhen Wang and Paneth, \{Nigel S.\} and Arturo Casadevall and Joyner, \{Michael J.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Mayo Foundation for Medical Education and Research",

year = "2021",

month = may,

doi = "10.1016/j.mayocp.2021.02.008",

language = "English",

volume = "96",

pages = "1262--1275",

journal = "Mayo Clinic Proceedings",

issn = "0025-6196",

publisher = "Elsevier Ltd.",

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}

Klassen, SA, Senefeld, JW, Johnson, PW, Carter, RE, Wiggins, CC, Shoham, S, Grossman, BJ, Henderson, JP, Musser, J, Salazar, E, Hartman, WR, Bouvier, NM, Liu, STH, Pirofski, LA, Baker, SE, van Helmond, N, Wright, RS, Fairweather, DL, Bruno, KA, Wang, Z, Paneth, NS, Casadevall, A & Joyner, MJ 2021, 'The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis', Mayo Clinic Proceedings, vol. 96, no. 5, pp. 1262-1275. https://doi.org/10.1016/j.mayocp.2021.02.008

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T1 - The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19

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AU - Klassen, Stephen A.

AU - Senefeld, Jonathon W.

AU - Johnson, Patrick W.

AU - Carter, Rickey E.

AU - Wiggins, Chad C.

AU - Shoham, Shmuel

AU - Grossman, Brenda J.

AU - Henderson, Jeffrey P.

AU - Musser, James

AU - Salazar, Eric

AU - Hartman, William R.

AU - Bouvier, Nicole M.

AU - Liu, Sean T.H.

AU - Pirofski, Liise anne

AU - Baker, Sarah E.

AU - van Helmond, Noud

AU - Wright, R. Scott

AU - Fairweather, De Lisa

AU - Bruno, Katelyn A.

AU - Wang, Zhen

AU - Paneth, Nigel S.

AU - Casadevall, Arturo

AU - Joyner, Michael J.

PY - 2021/5

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N2 - To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

AB - To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from 10 randomized clinical trials, 20 matched control studies, 2 dose-response studies, and 96 case reports or case series. Studies published between January 1, 2020, and January 16, 2021, were identified through a systematic search of online PubMed and MEDLINE databases. Random effects analyses of randomized clinical trials and matched control data demonstrated that patients with COVID-19 transfused with convalescent plasma exhibited a lower mortality rate compared with patients receiving standard treatments. Additional analyses showed that early transfusion (within 3 days of hospital admission) of higher titer plasma is associated with lower patient mortality. These data provide evidence favoring the efficacy of human convalescent plasma as a therapeutic agent in hospitalized patients with COVID-19.

UR - https://www.scopus.com/pages/publications/85105440274

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AN - SCOPUS:85105440274

SN - 0025-6196

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SP - 1262

EP - 1275

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

IS - 5

ER -

The Effect of Convalescent Plasma Therapy on Mortality Among Patients With COVID-19: Systematic Review and Meta-analysis

Abstract

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