The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters

J. E. Ottenweller; W. N. Tapp; B. H. Natelson

The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters

J. E. Ottenweller
, W. N. Tapp
, B. H. Natelson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digotoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.

Original language	English
Pages (from-to)	413-416
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	58
Issue number	3
State	Published - 1987
Externally published	Yes

Cite this

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title = "The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters",

abstract = "Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digotoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.",

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year = "1987",

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T1 - The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters

AU - Ottenweller, J. E.

AU - Tapp, W. N.

AU - Natelson, B. H.

PY - 1987

Y1 - 1987

N2 - Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digotoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.

AB - Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digotoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.

UR - https://www.scopus.com/pages/publications/0023626063

M3 - Article

C2 - 3438575

AN - SCOPUS:0023626063

SN - 0034-5164

VL - 58

SP - 413

EP - 416

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters

Abstract

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