The effect of background spatial contrast on electroretinographic responses in the human retina

Ivan Bodis-Wollner; Julie R. Brannan; Rita L. Storch; Mohammedyusuf E. Hajee; Manuela Minko

doi:10.1016/j.visres.2008.07.008

The effect of background spatial contrast on electroretinographic responses in the human retina

Ivan Bodis-Wollner, Julie R. Brannan, Rita L. Storch, Mohammedyusuf E. Hajee, Manuela Minko

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The electroretinogram (ERG) was obtained to contrast modulation (CM). This stimulus is a product of temporal modulation of the contrast of a spatial sinusoid at constant mean luminance. Mean contrast (10-40%), and modulation depth (25-1.0) were modulated at 7.5 Hz to record the pattern electroretinogram (PERG). The spatial pattern was a foveally fixated grating pattern with sinusoidal luminance profile with spatial frequency of 4.6 c/deg. CM resulted in significant first and second harmonic ERG responses. First harmonic amplitude increases then flattens as a function of mean contrast with ΔC = constant, while the second harmonic response remains unaffected by mean contrast. Apparently the first harmonic represents summed signals of local luminance responses arising from on and off neurons. Mean spatial contrast signals modulate preganglionic local luminance responses.

Original language	English
Pages (from-to)	922-930
Number of pages	9
Journal	Vision Research
Volume	49
Issue number	9
DOIs	https://doi.org/10.1016/j.visres.2008.07.008
State	Published - 11 May 2009
Externally published	Yes

Keywords

First and second harmonic responses
Human pattern electroretinogram
Local luminance
Spatial contrast

Access to Document

10.1016/j.visres.2008.07.008

Cite this

@article{5b4968773d34458a9965cc8433e3af3b,

title = "The effect of background spatial contrast on electroretinographic responses in the human retina",

abstract = "The electroretinogram (ERG) was obtained to contrast modulation (CM). This stimulus is a product of temporal modulation of the contrast of a spatial sinusoid at constant mean luminance. Mean contrast (10-40\%), and modulation depth (25-1.0) were modulated at 7.5 Hz to record the pattern electroretinogram (PERG). The spatial pattern was a foveally fixated grating pattern with sinusoidal luminance profile with spatial frequency of 4.6 c/deg. CM resulted in significant first and second harmonic ERG responses. First harmonic amplitude increases then flattens as a function of mean contrast with ΔC = constant, while the second harmonic response remains unaffected by mean contrast. Apparently the first harmonic represents summed signals of local luminance responses arising from on and off neurons. Mean spatial contrast signals modulate preganglionic local luminance responses.",

keywords = "First and second harmonic responses, Human pattern electroretinogram, Local luminance, Spatial contrast",

author = "Ivan Bodis-Wollner and Brannan, \{Julie R.\} and Storch, \{Rita L.\} and Hajee, \{Mohammedyusuf E.\} and Manuela Minko",

note = "Funding Information: Supported in part by NIH/NINDS, NPF and originally by EY01708. A portion of this research was presented at the 1989 meeting of the Association for Research and Ophthalmology. Nicoletta Berardi, Adriana Fiorentini, Ralph Nelson, and Paul Sieving contributed helpful review and suggestions on an early version of this paper and Martin Regan discussed the essential interpretation of our phase data. Areti Tzelepi indirectly contributed by modeling the retinal dopaminergic circuit (Bodis-Wollner, I., \& Tzelepi, A. (2002). Push–Pull model of dopamine{\textquoteright}s action in the retina. In G. K. Hung \& K. J. Ciuffreda (Eds.), Models of the visual system (pp. 191–214, chap. 5). New York, Boston, Dordrecht, London and Moscow: Kluwer Academic/Plenum Publishers). Leland H. Mylin was instrumental in various aspects of this study.",

year = "2009",

month = may,

day = "11",

doi = "10.1016/j.visres.2008.07.008",

language = "English",

volume = "49",

pages = "922--930",

journal = "Vision Research",

issn = "0042-6989",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - The effect of background spatial contrast on electroretinographic responses in the human retina

AU - Bodis-Wollner, Ivan

AU - Brannan, Julie R.

AU - Storch, Rita L.

AU - Hajee, Mohammedyusuf E.

AU - Minko, Manuela

N1 - Funding Information: Supported in part by NIH/NINDS, NPF and originally by EY01708. A portion of this research was presented at the 1989 meeting of the Association for Research and Ophthalmology. Nicoletta Berardi, Adriana Fiorentini, Ralph Nelson, and Paul Sieving contributed helpful review and suggestions on an early version of this paper and Martin Regan discussed the essential interpretation of our phase data. Areti Tzelepi indirectly contributed by modeling the retinal dopaminergic circuit (Bodis-Wollner, I., & Tzelepi, A. (2002). Push–Pull model of dopamine’s action in the retina. In G. K. Hung & K. J. Ciuffreda (Eds.), Models of the visual system (pp. 191–214, chap. 5). New York, Boston, Dordrecht, London and Moscow: Kluwer Academic/Plenum Publishers). Leland H. Mylin was instrumental in various aspects of this study.

PY - 2009/5/11

Y1 - 2009/5/11

N2 - The electroretinogram (ERG) was obtained to contrast modulation (CM). This stimulus is a product of temporal modulation of the contrast of a spatial sinusoid at constant mean luminance. Mean contrast (10-40%), and modulation depth (25-1.0) were modulated at 7.5 Hz to record the pattern electroretinogram (PERG). The spatial pattern was a foveally fixated grating pattern with sinusoidal luminance profile with spatial frequency of 4.6 c/deg. CM resulted in significant first and second harmonic ERG responses. First harmonic amplitude increases then flattens as a function of mean contrast with ΔC = constant, while the second harmonic response remains unaffected by mean contrast. Apparently the first harmonic represents summed signals of local luminance responses arising from on and off neurons. Mean spatial contrast signals modulate preganglionic local luminance responses.

AB - The electroretinogram (ERG) was obtained to contrast modulation (CM). This stimulus is a product of temporal modulation of the contrast of a spatial sinusoid at constant mean luminance. Mean contrast (10-40%), and modulation depth (25-1.0) were modulated at 7.5 Hz to record the pattern electroretinogram (PERG). The spatial pattern was a foveally fixated grating pattern with sinusoidal luminance profile with spatial frequency of 4.6 c/deg. CM resulted in significant first and second harmonic ERG responses. First harmonic amplitude increases then flattens as a function of mean contrast with ΔC = constant, while the second harmonic response remains unaffected by mean contrast. Apparently the first harmonic represents summed signals of local luminance responses arising from on and off neurons. Mean spatial contrast signals modulate preganglionic local luminance responses.

KW - First and second harmonic responses

KW - Human pattern electroretinogram

KW - Local luminance

KW - Spatial contrast

UR - https://www.scopus.com/pages/publications/67349139881

U2 - 10.1016/j.visres.2008.07.008

DO - 10.1016/j.visres.2008.07.008

M3 - Article

C2 - 18723047

AN - SCOPUS:67349139881

SN - 0042-6989

VL - 49

SP - 922

EP - 930

JO - Vision Research

JF - Vision Research

IS - 9

ER -

The effect of background spatial contrast on electroretinographic responses in the human retina

Abstract

Keywords

Access to Document

Fingerprint

Cite this