TY - JOUR
T1 - The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid
AU - Berger, Lawrence
AU - Gerson, Charles D.
AU - Yü, Ts'Ai Fan
N1 - Funding Information:
From the Department of Medicine, Mount Sinai School of Medicine, The City University of New York, New York, New York. This study was supported in part by Grant-in-Aid A-162 from the National Institute of Arthritis, Metabolism and Digestive Diseases, National institutes of Heatth, and The National Foundation for lleitis and Colitis, Inc. Requests for reprints should be addressed to Dr. Ts’Ai-Fan Yu, Department of Medicine, The Mount Sinai School of Medicine of the City University of New York, Fifth Avenue and 100th Street, New York, New York 10029. Manuscript accepted May 12, 1976.
PY - 1977/1
Y1 - 1977/1
N2 - Under spontaneous conditions in man and dog, very little ascorbic acid is excreted in urine. Ascorbic acid clearance (Cascorbic acid) is promptly augmented when plasma ascorbic acid is increased by intravenous injection. No net tubular secretion of ascorbic acid is demonstrable in either man or dog when plasma ascorbic acid is elevated to levels as high as 12 mg/100 ml in man, and 28 mg/100 ml in the dog. Nevertheless, both in men and the Dalmatian dog, when the glomerular filtration rate (GFR) is decreased, excreted ascorbic acid in relation to the amount filtered is exaggerated so that Cascorbic acid:GFR approaches unity. It is possible that secreted ascorbic acid is masked under ordinary circumstances, with a more significant contribution of secreted ascorbic acid to total urinary ascorbic acid becoming apparent under conditions of low GFR. In man, when the plasma ascorbic acid level is raised to above 6 mg/100 ml, Curate:GFR rises from control value of 0.081 ± 0.020, to 0.116 ± 0.026. In both mongrel and Dalmatian dogs an effect of ascorbic acid on urate excretion is not conclusively shown. The uricosuric effect of ascorbic acid in man may be due to competition with uric acid for renal tubular reabsorptive transport. The difference in the metabolism of ascorbic acid in the dog as compared to man may help account for the inconsistent effect of ascorbic acid on uric acid excretion in the dog.
AB - Under spontaneous conditions in man and dog, very little ascorbic acid is excreted in urine. Ascorbic acid clearance (Cascorbic acid) is promptly augmented when plasma ascorbic acid is increased by intravenous injection. No net tubular secretion of ascorbic acid is demonstrable in either man or dog when plasma ascorbic acid is elevated to levels as high as 12 mg/100 ml in man, and 28 mg/100 ml in the dog. Nevertheless, both in men and the Dalmatian dog, when the glomerular filtration rate (GFR) is decreased, excreted ascorbic acid in relation to the amount filtered is exaggerated so that Cascorbic acid:GFR approaches unity. It is possible that secreted ascorbic acid is masked under ordinary circumstances, with a more significant contribution of secreted ascorbic acid to total urinary ascorbic acid becoming apparent under conditions of low GFR. In man, when the plasma ascorbic acid level is raised to above 6 mg/100 ml, Curate:GFR rises from control value of 0.081 ± 0.020, to 0.116 ± 0.026. In both mongrel and Dalmatian dogs an effect of ascorbic acid on urate excretion is not conclusively shown. The uricosuric effect of ascorbic acid in man may be due to competition with uric acid for renal tubular reabsorptive transport. The difference in the metabolism of ascorbic acid in the dog as compared to man may help account for the inconsistent effect of ascorbic acid on uric acid excretion in the dog.
UR - http://www.scopus.com/inward/record.url?scp=0017363708&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(77)90351-5
DO - 10.1016/0002-9343(77)90351-5
M3 - Article
C2 - 835593
AN - SCOPUS:0017363708
SN - 0002-9343
VL - 62
SP - 71
EP - 76
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 1
ER -