The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit

Graeme H. Willies; Clifford J. Woolf; Clive Rosendorff

doi:10.1007/BF00585155

The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit

Graeme H. Willies
, Clifford J. Woolf
, Clive Rosendorff

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An exotoxin of Bacillus thuringiensis known to inhibit adenylate cyclase in vitro has been used to investigate the role of cyclic AMP in the pathogenesis of fever in the rabbit. Intra-hypothalamic microinjections of the exotoxin are non-pyrogenic and significantly attenuate the hyperthermia caused by intrahypothalamic microinjections of both bacterial pyrogen (endotoxin) and prostaglandin E₁. The hyperthermia produced by dibutyryl cyclic AMP is not affected by the exotoxin. These results support the idea that adenylate cyclase is activated during the development of fever in the rabbit.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Pflugers Archiv European Journal of Physiology
Volume	367
Issue number	2
DOIs	https://doi.org/10.1007/BF00585155
State	Published - Jan 1976
Externally published	Yes

Keywords

Adenylate cyclase inhibition
Cyclic AMP
Fever
Prostaglandin E
Pyrogen

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10.1007/BF00585155

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title = "The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit",

abstract = "An exotoxin of Bacillus thuringiensis known to inhibit adenylate cyclase in vitro has been used to investigate the role of cyclic AMP in the pathogenesis of fever in the rabbit. Intra-hypothalamic microinjections of the exotoxin are non-pyrogenic and significantly attenuate the hyperthermia caused by intrahypothalamic microinjections of both bacterial pyrogen (endotoxin) and prostaglandin E1. The hyperthermia produced by dibutyryl cyclic AMP is not affected by the exotoxin. These results support the idea that adenylate cyclase is activated during the development of fever in the rabbit.",

keywords = "Adenylate cyclase inhibition, Cyclic AMP, Fever, Prostaglandin E, Pyrogen",

author = "Willies, \{Graeme H.\} and Woolf, \{Clifford J.\} and Clive Rosendorff",

year = "1976",

month = jan,

doi = "10.1007/BF00585155",

language = "English",

volume = "367",

pages = "177--181",

journal = "Pflugers Archiv European Journal of Physiology",

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T1 - The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit

AU - Willies, Graeme H.

AU - Woolf, Clifford J.

AU - Rosendorff, Clive

PY - 1976/1

Y1 - 1976/1

N2 - An exotoxin of Bacillus thuringiensis known to inhibit adenylate cyclase in vitro has been used to investigate the role of cyclic AMP in the pathogenesis of fever in the rabbit. Intra-hypothalamic microinjections of the exotoxin are non-pyrogenic and significantly attenuate the hyperthermia caused by intrahypothalamic microinjections of both bacterial pyrogen (endotoxin) and prostaglandin E1. The hyperthermia produced by dibutyryl cyclic AMP is not affected by the exotoxin. These results support the idea that adenylate cyclase is activated during the development of fever in the rabbit.

AB - An exotoxin of Bacillus thuringiensis known to inhibit adenylate cyclase in vitro has been used to investigate the role of cyclic AMP in the pathogenesis of fever in the rabbit. Intra-hypothalamic microinjections of the exotoxin are non-pyrogenic and significantly attenuate the hyperthermia caused by intrahypothalamic microinjections of both bacterial pyrogen (endotoxin) and prostaglandin E1. The hyperthermia produced by dibutyryl cyclic AMP is not affected by the exotoxin. These results support the idea that adenylate cyclase is activated during the development of fever in the rabbit.

KW - Adenylate cyclase inhibition

KW - Cyclic AMP

KW - Fever

KW - Prostaglandin E

KW - Pyrogen

UR - https://www.scopus.com/pages/publications/0017029083

U2 - 10.1007/BF00585155

DO - 10.1007/BF00585155

M3 - Article

C2 - 189286

AN - SCOPUS:0017029083

SN - 0031-6768

VL - 367

SP - 177

EP - 181

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

IS - 2

ER -

The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit

Abstract

Keywords

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