The effect of altered thyroid function on the ultrastructure of the human liver

F. M. Klion, R. Segal, F. Schaffner

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Utrastructural studies of liver biopsy specimens from seven patients with thyrotoxicosis, and for comparison, two with myxedema, revealed nonspecific abnormalities of the hepatocytic organelles. The mitochondria of the hyperthyroid patients were enlarged, and megamitochondria were frequent. The smooth endoplasmic reticulum was hypertrophic, and glycogen was decreased. These effects appeared to be Actaptive in nature and were not reflected in abnormalities of hepatic tests. Whether the changes are caused by thyroxine or are secondary to metabolic alterations of the hyperthyroid state could not be determined.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalAmerican Journal of Medicine
Volume50
Issue number3
DOIs
StatePublished - Mar 1971

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