Keyphrases
Methotrexate
100%
Pharmacokinetics
100%
ABCG2
100%
ABCC4
100%
Area under the Concentration-time Curve
36%
Microdialysis
18%
Rank Order
18%
Chemotherapy
9%
Brain Regions
9%
4-fold
9%
Blood-brain Barrier
9%
C57BL
9%
Blood-brain Barrier Penetration
9%
Mouse Strain
9%
Primary Central Nervous System Lymphoma (PCNSL)
9%
Systemic Exposure
9%
Double Knockout
9%
Partition Coefficient
9%
Fluid Concentration
9%
High-dose Therapy
9%
Renal Excretion
9%
Brain Interstitial Fluid
9%
Brain Microdialysis
9%
Drug Transporters
9%
Biliary Excretion
9%
Drug Efflux Pump
9%
Brain Accumulation
9%
Biochemistry, Genetics and Molecular Biology
Pharmacokinetics
100%
Methotrexate
100%
ABCG2
100%
ABCC4
100%
Microdialysis
22%
Blood Brain Barrier
22%
Ordo
22%
Drug Megadose
11%
Wild Type
11%
Liquid
11%
C57BL Mouse
11%
Urinary Excretion
11%
Biliary Excretion
11%
Partition Coefficient
11%
Immunology and Microbiology
Methotrexate
100%
Pharmacokinetics
100%
ABCG2
100%
Blood Plasma
33%
Ordo
22%
Blood Brain Barrier
22%
Microdialysis
22%
Drug Megadose
11%
Wild Type
11%
Central Nervous System
11%
Partition Coefficient
11%
Urinary Excretion
11%
C57BL Mouse
11%
Biliary Excretion
11%
Brain Interstitial Fluid
11%
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacokinetics
100%
Methotrexate
100%
ABCG2
100%
Microdialysis
22%
Blood-Brain Barrier
22%
Effusion
22%
Chemotherapy
11%
Renal Excretion
11%
Biliary Excretion
11%
C57BL Mouse
11%
Primary Central Nervous System Lymphoma
11%
Neuroscience
Pharmacokinetics
100%
Methotrexate
100%
Breast Cancer Resistance Protein
100%
Blood Brain Barrier
22%
Microdialysis
22%
Brain Areas
11%
Interstitial Fluid
11%
Primary Central Nervous System Lymphoma
11%