The EBV-carrying, β2M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients

Erik Svedmyr, George Klein, Ola Weiland

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12 Scopus citations

Abstract

The β2-microglobulin/HLA deficient Burkitt lymphoma line Daudi was tested for sensitivity to EBV-specific cytotoxicity mediated by natural killer (NK)-depleted T-cells from acute mononucleosis patients. While the Daudi line was not as sensitive as the reference EBV-genome-positive target line, it was clearly sensitive in the majority of cases. This would speak against a major role of syngeneic restriction in this system.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalCancer Letters
Volume7
Issue number1
DOIs
StatePublished - Jun 1979
Externally publishedYes

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