The EBV-carrying, β2M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients

Erik Svedmyr; George Klein; Ola Weiland

doi:10.1016/S0304-3835(79)80071-3

The EBV-carrying, β₂M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients

Erik Svedmyr, George Klein, Ola Weiland

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12 Scopus citations

Abstract

The β₂-microglobulin/HLA deficient Burkitt lymphoma line Daudi was tested for sensitivity to EBV-specific cytotoxicity mediated by natural killer (NK)-depleted T-cells from acute mononucleosis patients. While the Daudi line was not as sensitive as the reference EBV-genome-positive target line, it was clearly sensitive in the majority of cases. This would speak against a major role of syngeneic restriction in this system.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Cancer Letters
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(79)80071-3
State	Published - Jun 1979
Externally published	Yes

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10.1016/S0304-3835(79)80071-3

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title = "The EBV-carrying, β2M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients",

abstract = "The β2-microglobulin/HLA deficient Burkitt lymphoma line Daudi was tested for sensitivity to EBV-specific cytotoxicity mediated by natural killer (NK)-depleted T-cells from acute mononucleosis patients. While the Daudi line was not as sensitive as the reference EBV-genome-positive target line, it was clearly sensitive in the majority of cases. This would speak against a major role of syngeneic restriction in this system.",

author = "Erik Svedmyr and George Klein and Ola Weiland",

note = "Funding Information: This project has been funded in part with federal funds from the Department of Health, Education and Welf;~re on Contract NO1 CP 33316, the Swedish Cancer Society and King Gustaf V Jubilee Fund.",

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AU - Klein, George

AU - Weiland, Ola

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AB - The β2-microglobulin/HLA deficient Burkitt lymphoma line Daudi was tested for sensitivity to EBV-specific cytotoxicity mediated by natural killer (NK)-depleted T-cells from acute mononucleosis patients. While the Daudi line was not as sensitive as the reference EBV-genome-positive target line, it was clearly sensitive in the majority of cases. This would speak against a major role of syngeneic restriction in this system.

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The EBV-carrying, β2M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients

Abstract

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The EBV-carrying, β₂M/HLA deficient Burkitt lymphoma line Daudi is sensitive to EBV-specific killer T-cells of mononucleosis patients