Abstract
TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin proteasome pathway. Thus, the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.
| Original language | English |
|---|---|
| Article number | e1372867 |
| Journal | Molecular and Cellular Oncology |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2 Nov 2017 |
| Externally published | Yes |
Keywords
- Autophagy
- CHIP
- STUB1
- TFEB
- proteasome
- ubiquitin