The "Domino Theory" of Hunger: The Hypothalamus Is Hot

Charles V. Mobbs

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations


Mechanisms by which the hypothalamus senses nutritional status are important for many metabolic diseases, including obesity and diabetes. Now, Coppola et al. (2007) report that hypothalamic neurons sense nutritional deficit through a cascade of events involving leptin, corticosterone, and glial production of thyroid hormone, leading to neuronal induction of uncoupling protein.

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalCell Metabolism
Issue number1
StatePublished - Jan 2007
Externally publishedYes


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