TY - JOUR
T1 - The diagnostic contribution of indocyanine green to fluorescein angiography in fellow drusen eyes of patients with wet age-related macular degeneration
AU - Landa, Gennady
AU - Springer, A.
AU - Bukelman, A.
AU - Pollack, A.
N1 - Funding Information:
We are grateful to B. Pine, J. Hoxmeier, J. Johnson, J. Willitzer, G. Kim, S. Ludsin, and J. Putman for their assistance in the field. We also thank D. Pavlik and T. DeVries for their assistance in the laboratory. Comments were provided by M. Bre-migan, J. Feminella, M. Maceina, S. Szedlmayer, and two anonymous reviewers that helped to improve this paper. This research was supported in part by Federal Aid in Fish Restoration Project F40-R administered by the Alabama Game and Fish Division, and National Science Foundation grants DEB-9108986 and DEB-9410323 to D.R.D. This manuscript is publication 8-975854 of the Alabama Agricultural Experiment Station.
PY - 2007
Y1 - 2007
N2 - PURPOSE. To assess the contribution of indocyanine green angiography (ICGA) to fluorescein angiography (FA) in evaluating fellow drusen eyes of patients with wet age-related macular degeneration (AMD) in the other eye. METHODS. The records of paired FA and ICGA of patients with dry AMD in one eye and wet AMD in the other eye were retrospectively reviewed. Based on color fundus photographs, drusen were graded to low, moderate, or high grade of severity on FA. The FA and ICGA findings were compared. RESULTS. Fifty-two pairs of eyes were included. Fluorescein angiography showed drusen of low severity in 11 (21.2%) eyes, of moderate severity in 31 (59.6%), and of high severity in 10 (19.2%). Leakage on both FA and ICGA was not demonstrated in any case of drusen of low or moderate severity. Only in 2 out of 10 eyes from the high severity group, 3.8% of the eyes of the whole study population, did ICGA reveal occult choroidal neovascularization (CNV) that was not observed on FA. CONCLUSIONS. In selected eyes with drusen of high grade severity, ICGA may detect occult CNV, unrecognized clinically or by FA. ICGA had a small contribution to the diagnosis of occult CNV in fellow drusen eyes with any degree of severity.
AB - PURPOSE. To assess the contribution of indocyanine green angiography (ICGA) to fluorescein angiography (FA) in evaluating fellow drusen eyes of patients with wet age-related macular degeneration (AMD) in the other eye. METHODS. The records of paired FA and ICGA of patients with dry AMD in one eye and wet AMD in the other eye were retrospectively reviewed. Based on color fundus photographs, drusen were graded to low, moderate, or high grade of severity on FA. The FA and ICGA findings were compared. RESULTS. Fifty-two pairs of eyes were included. Fluorescein angiography showed drusen of low severity in 11 (21.2%) eyes, of moderate severity in 31 (59.6%), and of high severity in 10 (19.2%). Leakage on both FA and ICGA was not demonstrated in any case of drusen of low or moderate severity. Only in 2 out of 10 eyes from the high severity group, 3.8% of the eyes of the whole study population, did ICGA reveal occult choroidal neovascularization (CNV) that was not observed on FA. CONCLUSIONS. In selected eyes with drusen of high grade severity, ICGA may detect occult CNV, unrecognized clinically or by FA. ICGA had a small contribution to the diagnosis of occult CNV in fellow drusen eyes with any degree of severity.
KW - Fluorescein angiography
KW - Indocyanine green angiography
KW - Wet age-related macular degeneration
UR - http://www.scopus.com/inward/record.url?scp=35348993728&partnerID=8YFLogxK
U2 - 10.1177/112067210701700421
DO - 10.1177/112067210701700421
M3 - Article
C2 - 17671939
AN - SCOPUS:35348993728
SN - 1120-6721
VL - 17
SP - 615
EP - 619
JO - European Journal of Ophthalmology
JF - European Journal of Ophthalmology
IS - 4
ER -