@article{83defab916ec437d868fa18401e3e2f9,
title = "The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease",
abstract = "The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all-cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia.",
keywords = "Alzheimer's disease, Cerebrospinal fluid, Dementia, Diagnosis, Magnetic resonance brain imaging, Positron emission tomography",
author = "McKhann, {Guy M.} and Knopman, {David S.} and Howard Chertkow and Hyman, {Bradley T.} and Jack, {Clifford R.} and Kawas, {Claudia H.} and Klunk, {William E.} and Koroshetz, {Walter J.} and Manly, {Jennifer J.} and Richard Mayeux and Mohs, {Richard C.} and Morris, {John C.} and Rossor, {Martin N.} and Philip Scheltens and Carrillo, {Maria C.} and Bill Thies and Sandra Weintraub and Phelps, {Creighton H.}",
note = "Funding Information: Guy McKhann serves on a Data Safety Monitoring Board for Merck. David Knopman serves on a Data Safety Monitoring Board for Lilly Pharmaceuticals and is an investigator for clinical trials sponsored by Elan Pharmaceuticals, Forest Pharmaceuticals, and Baxter Healthcare ; he is deputy editor of Neurology and receives compensation for editorial activities. Howard Chertkow serves as a consultant to Pfizer Canada, Lundbeck Canada, Janssen Ortho, Novartis Canada, and Bristol Myers Squibb; he receives a research grant from Pfizer Canada. Bradley Hyman serves as a consultant to EMD Serrano, Janssen, Takeda, BMS, Neurophage, Pfizer, Quanterix, foldrx, Elan, and Link, and receives funding from the NIH, the Alzheimer's Association, and Fidelity Biosciences. Clifford Jack serves as a consultant for Eli Lilly, Eisai, and {\'E}lan; he is an investigator in clinical trials sponsored by Baxter and Pfizer Inc., and owns stock in Johnson and Johnson. Claudia Kawas serves on a Data Safety Monitoring Board for Lilly Pharmaceuticals, Elan Pharmaceuticals, and Lundbeck; she is an investigator in a trial sponsored by Avid Radiopharmaceuticals. William Klunk serves as a consultant to GE Healthcare and receives research grants from the same; he also receives royalties from GE Healthcare for PiB PET technology and owns stock or options in Neuroptix, a company seeking to commercialize detection of amyloid in the eye. Walter Koroshetz are employees of the U.S. Government and report no conflicts. Jennifer Manly reports no conflicts of interests. Richard Mayeux serves on scientific advisory board of PsychoGenics. Richard Mohs is a full-time employee of Eli Lilly and Company and holds stock in Lilly. Avid Radiopharmaceuticals is a wholly owned subsidiary of Eli Lilly and Co. John Morris serves as a consultant to Astra Zeneca, Bristol-Myers Squibb, Eisai, Janssen, Genetic, Eli Lilly, Merck, Novartis, Otsuka, Pfizer, and Schering Plough. University College London receives payment for Martin Rossor serving on the Safety Monitoring Committees for Janssen and Servier trials in AD. Philip Scheltens serves as a consultant to Pfizer Pharmaceuticals, Genetech, Danone Research, Lundbeck Pharmaceuticals, GE Healthcare, Roche, and Novartis; he also serves on a speakers bureau for Lundbeck Pharmaceuticals. Maria Carrillo and Bill Thies are employees of the Alzheimer's Association and reports no conflicts. Sandra Weintraub reports no conflicts of interest and Creighton Phelps.",
year = "2011",
month = may,
doi = "10.1016/j.jalz.2011.03.005",
language = "English",
volume = "7",
pages = "263--269",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley and Sons Inc.",
number = "3",
}