The development of a Marjolin's cancer in a human immunodeficiency virus-positive hemophilic man and review of the literature

Afshin Rahimizadeh, Ron Shelton, Hubert Weinberg, Neil Sadick

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12 Scopus citations

Abstract

BACKGROUND. The malignant potential of chronic ulcers and scars secondary to a variety of injuries is well characterized in the medical literature. Furthermore, it has been reported that human immunodeficiency virus (HIV)-positive patients have a higher incidence of basal cell carcinoma (BCC) than the general population. OBJECTIVE. TO describe a case of an unusually aggressive morpheaform BCC that developed in a 28-year-old HIV- positive patient. The tumor developed in a scar 25 years after the initial trauma (Marjolin's ulcer). METHODS. Description of a case and review of the literature of Marjolins ulcer. RESULTS. The tumor was removed in a seven- stage, 21-section, micrographically controlled excision. Intraoperatively, perineural invasion of the infraorbital nerve was observed. The postoperative defect was repaired using a full-thickness skin graft. CONCLUSION. Although most malignancies arising within chronic scars are SCCs, BCCs and a number of other tumors have been described. Mohs micrographic surgery was effective in treating this aggressive morpheaform BCC. A high degree of suspicion in any changing healed scar is recommended.

Original languageEnglish
Pages (from-to)560-563
Number of pages4
JournalDermatologic Surgery
Volume23
Issue number7
DOIs
StatePublished - Jul 1997

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