The decision to enter mitosis: feedback and redundancy in the mitotic entry network

Arne Lindqvist, Verónica Rodríguez-Bravo, René H. Medema

Research output: Contribution to journalShort surveypeer-review

438 Scopus citations


The decision to enter mitosis is mediated by a network of proteins that regulate activation of the cyclin B-Cdk1 complex. Within this network, several positive feedback loops can amplify cyclin B-Cdk1 activation to ensure complete commitment to a mitotic state once the decision to enter mitosis has been made. However, evidence is accumulating that several components of the feedback loops are redundant for cyclin B-Cdk1 activation during normal cell division. Nonetheless, defned feedback loops become essential to promote mitotic entry when normal cell cycle progression is perturbed. Recent data has demonstrated that at least three Plk1-dependent feedback loops exist that enhance cyclin B-Cdk1 activation at different levels. In this review, we discuss the role of various feedback loops that regulate cyclin B-Cdk1 activation under different conditions, the timing of their activation, and the possible identity of the elusive trigger that controls mitotic entry in human cells.

Original languageEnglish
Pages (from-to)193-202
Number of pages10
JournalJournal of Cell Biology
Issue number2
StatePublished - 20 Apr 2009
Externally publishedYes


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