The decarboxylative strecker reaction

Deepankar Das; Matthew T. Richers; Longle Ma; Daniel Seidel

doi:10.1021/ol202957d

The decarboxylative strecker reaction

Deepankar Das
, Matthew T. Richers
, Longle Ma
, Daniel Seidel

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

Original language	English
Pages (from-to)	6584-6587
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1021/ol202957d
State	Published - 16 Dec 2011
Externally published	Yes

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title = "The decarboxylative strecker reaction",

abstract = "α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.",

author = "Deepankar Das and Richers, \{Matthew T.\} and Longle Ma and Daniel Seidel",

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doi = "10.1021/ol202957d",

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AU - Das, Deepankar

AU - Richers, Matthew T.

AU - Ma, Longle

AU - Seidel, Daniel

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Y1 - 2011/12/16

N2 - α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

AB - α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

UR - https://www.scopus.com/pages/publications/84055213667

U2 - 10.1021/ol202957d

DO - 10.1021/ol202957d

M3 - Article

C2 - 22087753

AN - SCOPUS:84055213667

SN - 1523-7060

VL - 13

SP - 6584

EP - 6587

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

The decarboxylative strecker reaction

Abstract

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