The decarboxylative strecker reaction

Deepankar Das; Matthew T. Richers; Longle Ma; Daniel Seidel

doi:10.1021/ol202957d

The decarboxylative strecker reaction

Deepankar Das, Matthew T. Richers, Longle Ma, Daniel Seidel

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

Original language	English
Pages (from-to)	6584-6587
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1021/ol202957d
State	Published - 16 Dec 2011
Externally published	Yes

Access to Document

10.1021/ol202957d

Cite this

@article{c8d76465e3474cdb8f344bdf2a2db1ca,

title = "The decarboxylative strecker reaction",

abstract = "α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.",

author = "Deepankar Das and Richers, {Matthew T.} and Longle Ma and Daniel Seidel",

year = "2011",

month = dec,

day = "16",

doi = "10.1021/ol202957d",

language = "English",

volume = "13",

pages = "6584--6587",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - The decarboxylative strecker reaction

AU - Das, Deepankar

AU - Richers, Matthew T.

AU - Ma, Longle

AU - Seidel, Daniel

PY - 2011/12/16

Y1 - 2011/12/16

N2 - α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

AB - α-Amino acids react with aldehydes in the presence of a cyanide source to form α-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable α-amino nitriles that are inaccessible by traditional Strecker chemistry.

UR - http://www.scopus.com/inward/record.url?scp=84055213667&partnerID=8YFLogxK

U2 - 10.1021/ol202957d

DO - 10.1021/ol202957d

M3 - Article

C2 - 22087753

AN - SCOPUS:84055213667

SN - 1523-7060

VL - 13

SP - 6584

EP - 6587

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

The decarboxylative strecker reaction

Abstract

Access to Document

Fingerprint

Cite this