The current role and future prospects of D-dimer Biomarker

Armaghan Y. Soomro, Alejandra Guerchicoff, Dru J. Nichols, Javed Suleman, George D. Dangas

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

D-dimers have been discovered as by-products of fibrinolysis. In situations where the fundamental pathology is associated with increased thrombolytic activity, D-dimer assays could serve an integral role in the clinical workup, and have an already established role in the diagnosis of clinical disorders of venous thromboembolism, and disseminated intravascular coagulation. However, there is growing literature suggesting that this is not the only clinical scenario where D-dimers may be of significance. They may also become an important biomarker in coronary and carotid artery atherosclerosis and aortic diseases. Being a non-invasive and quick means of diagnosis, D-dimers are a cost-effective tool used for diagnosing diseases.With the future being steered in the direction of preventive cardiology, it is imperative for clinicians to understand how to effectively utilize biomarkers in order to diagnose disorders. In this context, we review D-dimer's origin, current clinical utility, and potential future applications.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalEuropean Heart Journal - Cardiovascular Pharmacotherapy
Volume2
Issue number3
DOIs
StatePublished - 1 Jul 2016

Keywords

  • Acute coronary syndrome
  • Aortic disorders
  • Biomarkers

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