Objective: To study the cell toxicity of CNTs/HAP implant in white rat's gluteus maximus by observation of morphology change and VEGF expression. Method: The histology observation and RT-PCR analysis in rat's gluteus was studied at different time after the CNTs/HAP composites were implanted. Results: After 1 and 3 days the inflammation cells and lymphocyte infiltrated with edematous tissue and loose stroma were observed. After 5 and 7 days the wall of blood vessel grew thick and the mononuclear macrophage and the fibrous tissue proliferated. Small amount of degenerated muscle fiber appeared and the VEGF expression increased. After 14 days the blood vessel of the pripheral fibrous tissue dilated, with a few pologistic cells infiltrating, at the same time tissue edema was not obvious and the VEGF expression decreased. Conclusion: The CNTs/HAP composite showed enhancement of blood vessel regeneration and has acceptable biocompatibility.
|Number of pages||3|
|Journal||Chinese Journal of Biomedical Engineering|
|State||Published - Oct 2005|
- Carbon nanotube/hydroxyapatite composite
- Skeletal muscle