The contemporary role of protamine in the cardiac catheterization laboratory

Barbara A. Danek; Kathleen E. Kearney; Christine J. Chung; Zachary Steinberg; William L. Lombardi; James M. McCabe; Lorenzo Azzalini

doi:10.1002/ccd.30679

The contemporary role of protamine in the cardiac catheterization laboratory

Barbara A. Danek, Kathleen E. Kearney, Christine J. Chung, Zachary Steinberg, William L. Lombardi, James M. McCabe, Lorenzo Azzalini

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Access to the arterial circulation and full anticoagulation carries a risk of serious bleeding during and after percutaneous coronary intervention. Important sources of bleeding include the arterial access site and coronary artery perforation. Prompt and effective management of hemorrhagic complications is an essential interventional skill. Protamine sulfate is well-known as a heparin reversal agent. Despite this, there is heterogeneity in the use of protamine during interventional procedures. While protamine is generally well-tolerated, it is associated with a risk of hypersensitivity reaction, including anaphylaxis, among others. The purpose of this review is to summarize the existing evidence about and experience with the use of protamine sulfate in the setting of percutaneous coronary and structural interventional procedures.

Original language	English
Pages (from-to)	111-120
Number of pages	10
Journal	Catheterization and Cardiovascular Interventions
Volume	102
Issue number	1
DOIs	https://doi.org/10.1002/ccd.30679
State	Published - 1 Jul 2023
Externally published	Yes

Keywords

bleeding
complications
perforation
protamine sulfate

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title = "The contemporary role of protamine in the cardiac catheterization laboratory",

abstract = "Access to the arterial circulation and full anticoagulation carries a risk of serious bleeding during and after percutaneous coronary intervention. Important sources of bleeding include the arterial access site and coronary artery perforation. Prompt and effective management of hemorrhagic complications is an essential interventional skill. Protamine sulfate is well-known as a heparin reversal agent. Despite this, there is heterogeneity in the use of protamine during interventional procedures. While protamine is generally well-tolerated, it is associated with a risk of hypersensitivity reaction, including anaphylaxis, among others. The purpose of this review is to summarize the existing evidence about and experience with the use of protamine sulfate in the setting of percutaneous coronary and structural interventional procedures.",

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AU - Danek, Barbara A.

AU - Kearney, Kathleen E.

AU - Chung, Christine J.

AU - Steinberg, Zachary

AU - Lombardi, William L.

AU - McCabe, James M.

AU - Azzalini, Lorenzo

PY - 2023/7/1

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N2 - Access to the arterial circulation and full anticoagulation carries a risk of serious bleeding during and after percutaneous coronary intervention. Important sources of bleeding include the arterial access site and coronary artery perforation. Prompt and effective management of hemorrhagic complications is an essential interventional skill. Protamine sulfate is well-known as a heparin reversal agent. Despite this, there is heterogeneity in the use of protamine during interventional procedures. While protamine is generally well-tolerated, it is associated with a risk of hypersensitivity reaction, including anaphylaxis, among others. The purpose of this review is to summarize the existing evidence about and experience with the use of protamine sulfate in the setting of percutaneous coronary and structural interventional procedures.

AB - Access to the arterial circulation and full anticoagulation carries a risk of serious bleeding during and after percutaneous coronary intervention. Important sources of bleeding include the arterial access site and coronary artery perforation. Prompt and effective management of hemorrhagic complications is an essential interventional skill. Protamine sulfate is well-known as a heparin reversal agent. Despite this, there is heterogeneity in the use of protamine during interventional procedures. While protamine is generally well-tolerated, it is associated with a risk of hypersensitivity reaction, including anaphylaxis, among others. The purpose of this review is to summarize the existing evidence about and experience with the use of protamine sulfate in the setting of percutaneous coronary and structural interventional procedures.

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The contemporary role of protamine in the cardiac catheterization laboratory

Abstract

Keywords

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