@article{b7a2b14f05e746e89e5fab70db540eed,
title = "The comparative effects of isoprinosine, levamisole, muramyl dipeptide and SM1213 on lymphocyte and macrophage proliferation and activation in vitro",
abstract = "Four immunopotentiators, levamisole, isoprinosine, muramyl dipeptide (MDP) and SM1213 were analysed in vitro on phytohemagglutinin-induced lymphocyte proliferation and lymphokine-induced macrophage proliferation and activation to kill Listeria monocytogenes. Levamisole and isoprinosine augmented all three functions. MDP and SM1213 induced macrophage activation directly. The effects of these agents on these cells at concentrations relevant to in vivo therapy supports their immunopharmacologic capacity to modify cellular immunity.",
author = "Hadden, {John W.} and Arthur Englard and Sadlik, {John R.} and Hadden, {Elba M.}",
note = "Funding Information: Isoprinosine (Inosiplex) is a complex of p-acetamidobenzoic acid, N,N-dimethylamino-2-propanol and inosine (3:1 molar ratio) (Simon & Glasky, 1978), which has been employed experimentally as an antiviral agent. In vitro studies (Hadden, Hadden & * This work was supported by grants-in-aid from the National Institutes of Health, Newport Pharmaceuticals International, Strategic Medical Research Corporation, The American Heart Association, and the Alton Jones Foundation. 17 Coffey 1976b) indicate that this agent is active on lymphocytes and have led to its evaluation as an immunopotentiator (Simon & Glasky, 1978).",
year = "1979",
doi = "10.1016/0192-0561(79)90026-2",
language = "English",
volume = "1",
pages = "17--27",
journal = "International Journal of Immunopharmacology",
issn = "0192-0561",
publisher = "Elsevier B.V.",
number = "1",
}