@article{1a5dba05c8e441f6aa419863daaa7711,
title = "The combination of nondipper pulse rate pattern and nighttime high pulse rate variability is associated with an increase of brain natriuretic peptide: the J-HOP study",
abstract = "The association between pulse rate (PR) and short-term PR variability and hypertensive organ damage has not been clarified. We enrolled 1439 patients from the J-HOP study. We calculated the standard deviation (SD) of PR in the nighttime using nighttime PR measurements at 30-min intervals. The SDs of PR (PR-SD) at nighttime were divided into quartiles (Q1–Q4). Nondipper PR was defined as (awake PR-sleep PR) < 0.1. Brain natriuretic peptide (BNP) levels were higher in patients with nondipper PR status in Q4 of PR-SD (nondipper PR/PR-SD Q4) than those with nondipper PR/PR-SD Q1–Q3 (37.8 vs 21.9 pg/mL, p = 0.041). The percentage of BNP > 100 pg/mL for patients with dipper PR/PR-SD Q1–Q3 was 5.2%, that for dipper PR/PR-SD Q4 was 4.8%, that for nondipper PR/PR-SD Q1–Q3 was 13.0%, and that for nondipper PR/PR-SD Q4 was 20.0% (ANOVA p < 0.001). In conclusion, BNP was high in patients having nondipper PR and high nocturnal PR-SD. [Figure not available: see fulltext.].",
keywords = "Cardiovascular events, Heart failure, Hypertension, Organ damage, Sympathetic nervous system",
author = "Tomoyuki Kabutoya and Satoshi Hoshide and Kazuomi Kario",
note = "Funding Information: This study was financially supported in part by a grant from the 21st Century Center of Excellence Project run by Japan{\textquoteright}s Ministry of Education, Culture, Sports, Science, and Technology (MEXT); a grant from the Foundation for Development of the Community (Tochigi); a grant from Omron Healthcare Co., Ltd; a Grant-in-Aid for Scientific Research (B; 21390247) from The Ministry of Education, Culture, Sports, Science, and Technology of Japan; and funds from the MEXT-supported program for the Strategic Research Foundation at Private Universities, 2011 to 2015 Cooperative Basic and Clinical Research on Circadian Medicine (S1101022) to KK. The funding sponsors had no role in the study design or conduct of the study; in the collection, management, analysis, or interpretation of the data; in the preparation of the article; or in the decision to submit the article for publication. Funding Information: KK received research funding from Omron Healthcare Co, Fukuda Denshi, and A&D Co. The other authors report no conflicts. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to The Japanese Society of Hypertension.",
year = "2023",
month = apr,
doi = "10.1038/s41440-022-01130-9",
language = "English",
volume = "46",
pages = "1044--1048",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "4",
}