The Collicular–Pulvinar–Amygdala Axis and Adult-Onset Idiopathic Focal Dystonias

Shameer Rafee, Michael Hutchinson, Richard Reilly

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Adult-onset idiopathic focal dystonias (AOIFD) are the most common type of dystonia. It has varied expression including multiple motor (depending on body part affected) and non-motor symptoms (psychiatric, cognitive and sensory). The motor symptoms are usually the main reason for presentation and are most often treated with botulinum toxin. However, non-motor symptoms are the main predictors of quality of life and should be addressed appropriately, as well as treating the motor disorder. Rather than considering AOIFD as a movement disorder, a syndromic approach should be taken, one that accommodates all the symptoms. Dysfunction of the collicular–pulvinar–amygdala axis, with the superior colliculus as a central node, can explain the diverse expression of this syndrome.

Original languageEnglish
Title of host publicationAdvances in Neurobiology
PublisherSpringer
Pages195-210
Number of pages16
DOIs
StatePublished - 2023
Externally publishedYes

Publication series

NameAdvances in Neurobiology
Volume31
ISSN (Print)2190-5215
ISSN (Electronic)2190-5223

Keywords

  • Collicular–pulvinar–amygdala axis
  • Focal dystonias
  • Mood disorders
  • Non-motor
  • Superior colliculus

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