The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

D. J. Straus; M. Andreeff; H. J. Hansen; R. Mertelsmann; B. Koziner; R. Chaganti; T. S. Gee; S. McKenzie; M. R. Melamed; B. D. Clarkson

doi:10.1182/blood.v54.6.1428.1428

The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

D. J. Straus
, M. Andreeff
, H. J. Hansen
, R. Mertelsmann
, B. Koziner
, R. Chaganti
, T. S. Gee
, S. McKenzie
, M. R. Melamed
, B. D. Clarkson

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

Original language	English
Pages (from-to)	1428-1433
Number of pages	6
Journal	Blood
Volume	54
Issue number	6
DOIs	https://doi.org/10.1182/blood.v54.6.1428.1428
State	Published - 1979
Externally published	Yes

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10.1182/blood.v54.6.1428.1428

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Straus, D. J., Andreeff, M., Hansen, H. J., Mertelsmann, R., Koziner, B., Chaganti, R., Gee, T. S., McKenzie, S., Melamed, M. R., & Clarkson, B. D. (1979). The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis. Blood, 54(6), 1428-1433. https://doi.org/10.1182/blood.v54.6.1428.1428

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title = "The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis",

abstract = "Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84\% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.",

author = "Straus, \{D. J.\} and M. Andreeff and Hansen, \{H. J.\} and R. Mertelsmann and B. Koziner and R. Chaganti and Gee, \{T. S.\} and S. McKenzie and Melamed, \{M. R.\} and Clarkson, \{B. D.\}",

year = "1979",

doi = "10.1182/blood.v54.6.1428.1428",

language = "English",

volume = "54",

pages = "1428--1433",

journal = "Blood",

issn = "0006-4971",

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TY - JOUR

T1 - The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

AU - Straus, D. J.

AU - Andreeff, M.

AU - Hansen, H. J.

AU - Mertelsmann, R.

AU - Koziner, B.

AU - Chaganti, R.

AU - Gee, T. S.

AU - McKenzie, S.

AU - Melamed, M. R.

AU - Clarkson, B. D.

PY - 1979

Y1 - 1979

N2 - Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

AB - Measurement of cellular DNA content by flow cytometry demonstrated presence of two distinct aneuploid neoplasms in a patient who developed acute myeloblastic leukemia (AML) 4 mo after diagnosis of diffuse histiocytic lymphoma (DHL). A lymph node aspirate contained peroxidase-negative, 'null', hyperdiploid (2.6C) DHL cells, while the bone marrow (BM) contained 84% primitive peroxidase-positive tetraploid AML cells (4.0C). Minor populations of hyperdiploid DHL and normal diploid cells could be detected by flow-cytometry in the BM, and all three populations were also seen in the peripheral blood.

UR - https://www.scopus.com/pages/publications/0018667205

U2 - 10.1182/blood.v54.6.1428.1428

DO - 10.1182/blood.v54.6.1428.1428

M3 - Article

C2 - 292459

AN - SCOPUS:0018667205

SN - 0006-4971

VL - 54

SP - 1428

EP - 1433

JO - Blood

JF - Blood

IS - 6

ER -

The coexistence of acute myeloblastic leukemia and diffuse histiocytic lymphoma in the same patient as demonstrated by multiparameter analysis

Abstract

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