TY - JOUR
T1 - The clinical and prognostic significance of activated AKT-mTOR pathway in human astrocytomas
AU - El Habr, Elias A.
AU - Adamopoulos, Christos
AU - Levidou, Georgia
AU - Saetta, Aggeliki A.
AU - Korkolopoulou, Penelope
AU - Piperi, Christina
PY - 2012
Y1 - 2012
N2 - Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are "endowed" with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
AB - Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are "endowed" with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
UR - http://www.scopus.com/inward/record.url?scp=84866184262&partnerID=8YFLogxK
U2 - 10.1155/2012/454957
DO - 10.1155/2012/454957
M3 - Review article
AN - SCOPUS:84866184262
SN - 2090-1852
VL - 2012
JO - Neurology Research International
JF - Neurology Research International
M1 - 454957
ER -