The characteristics of induced N-demethylase of aminopyrine

K. E. Gerasimov, D. V. Mitrofanov, I. B. Tsyrlov

Research output: Contribution to journalArticlepeer-review


The study of the inducing effect of phenobarbital on the activity of N-demethylase of aminopyrine in the rat liver microsomes revealed the correlation of the rate of enzymic reaction with the changes in the maximum binding of aminopyrine by cytochrome P-450 rather than with the content of hemoproteid itself. The comparison of the activity of N-demethylation of aminopyrine in control and phenobarbital-induced rats showed the quantitative correspondence of the yield of products of the reaction-formaldehyde in the liver microsomes and 4-aminoantipyrine in the urine samples. Self-induction of N-demethylating activity at repeated aminopyrine administration to rats and the dose dependence of this phenomenon were found.

Original languageEnglish
Pages (from-to)86-88
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number3
StatePublished - 1986
Externally publishedYes


Dive into the research topics of 'The characteristics of induced N-demethylase of aminopyrine'. Together they form a unique fingerprint.

Cite this