TY - JOUR
T1 - The change in kidney function was associated with carotid artery plaque in a community-based population
T2 - A cohort study
AU - Xu, Renying
AU - Cai, Hong
AU - Fan, Zhuping
AU - Wan, Yanping
AU - Gao, Xiang
N1 - Publisher Copyright:
© 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
PY - 2021/1/4
Y1 - 2021/1/4
N2 - Background and aims: We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population. Methods and results: A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6 ± 11.6 years) free of chronic kidney diseases were enrolled. The change in eGFR was calculated based on two measurements in 2013 and 2014 (mean interval: 1.2 y). Participants were further classified into three groups based on the change in eGFR: fast-decrease (<-3.3%), stable (from −3.3% to 3.3%), and fast-increase (≥3.3%). CAP was annually assessed by ultrasound B model throughout the study (2013–2018). We have identified 1,624 new cases of CAP (16.0 per 1000 person-year) during follow up. Compared to participants with stable eGFR, participants in both fast-decrease and fast-increase groups were associated with 1.99 folds (HR = 1.99, 95% CI: 1.54, 2.57) and 3.15 folds (HR = 3.15, 95% CI: 2.38, 4.16) higher likelihood of developing CAP. The association between continuous change in eGFR and the risk of CAP demonstrate a “U” shape. Sensitivity analysis generated similar results with main analysis. Conclusions: Both fast decrease and increase in eGFR were associated with the risk of developing CAP in Chinese adults.
AB - Background and aims: We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population. Methods and results: A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6 ± 11.6 years) free of chronic kidney diseases were enrolled. The change in eGFR was calculated based on two measurements in 2013 and 2014 (mean interval: 1.2 y). Participants were further classified into three groups based on the change in eGFR: fast-decrease (<-3.3%), stable (from −3.3% to 3.3%), and fast-increase (≥3.3%). CAP was annually assessed by ultrasound B model throughout the study (2013–2018). We have identified 1,624 new cases of CAP (16.0 per 1000 person-year) during follow up. Compared to participants with stable eGFR, participants in both fast-decrease and fast-increase groups were associated with 1.99 folds (HR = 1.99, 95% CI: 1.54, 2.57) and 3.15 folds (HR = 3.15, 95% CI: 2.38, 4.16) higher likelihood of developing CAP. The association between continuous change in eGFR and the risk of CAP demonstrate a “U” shape. Sensitivity analysis generated similar results with main analysis. Conclusions: Both fast decrease and increase in eGFR were associated with the risk of developing CAP in Chinese adults.
KW - Adults
KW - Carotid artery plaque (CAP)
KW - Chronic kidney disease
KW - Estimated glomerular filtration rate (eGFR)
UR - http://www.scopus.com/inward/record.url?scp=85091688545&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2020.08.016
DO - 10.1016/j.numecd.2020.08.016
M3 - Article
C2 - 32994120
AN - SCOPUS:85091688545
SN - 0939-4753
VL - 31
SP - 119
EP - 126
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 1
ER -