TY - JOUR
T1 - The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures
AU - Qin, Weiping
AU - Sun, Li
AU - Cao, Jay
AU - Peng, Yuanzhen
AU - Collier, Lauren
AU - Wu, Yong
AU - Creasey, Graham
AU - Li, Jianhua
AU - Qin, Yiwen
AU - Jarvis, Jonathan
AU - Bauman, William A.
AU - Zaidi, Mone
AU - Cardozo, Christopher
PY - 2013/5/10
Y1 - 2013/5/10
N2 - Background: Mechanisms by which muscle regulates bone are poorly understood. Results: Electrically stimulated muscle contraction reversed elevations in bone resorption and increased Wnt signaling in bone-derived cells after spinal cord transection. Conclusion: Muscle contraction reduced resorption of unloaded bone independently of the CNS, through mechanical effects and, potentially, nonmechanical signals (e.g. myokines). Significance: The study provides new insights regarding muscle-bone interactions.
AB - Background: Mechanisms by which muscle regulates bone are poorly understood. Results: Electrically stimulated muscle contraction reversed elevations in bone resorption and increased Wnt signaling in bone-derived cells after spinal cord transection. Conclusion: Muscle contraction reduced resorption of unloaded bone independently of the CNS, through mechanical effects and, potentially, nonmechanical signals (e.g. myokines). Significance: The study provides new insights regarding muscle-bone interactions.
UR - http://www.scopus.com/inward/record.url?scp=84877715751&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.454892
DO - 10.1074/jbc.M113.454892
M3 - Article
C2 - 23530032
AN - SCOPUS:84877715751
SN - 0021-9258
VL - 288
SP - 13511
EP - 13521
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 19
ER -