The cellular process of autophagy and control of autophagy in neurons

Nicole C. McKnight, Noboru Mizushima, Zhenyu Yue

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


Autophagy is a cell self-digestive, lysosomal degradation pathway. The three subtypes of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy, differ in the way that materials are delivered to the lysosomes for degradation. While recent studies reveal that the cellular process of macroautophagy (involving critical steps such as formation, trafficking, fusion and degradation of autophagosomes) is evolutionarily conserved from yeast to mammals, the regulation and functional adaptation of autophagy in various cells and tissues is poorly understood. This chapter provides an overview of what is known about autophagy machinery and highlights the recent findings of autophagy regulation in neurons. Elucidation of neuronal autophagy function will ultimately aid in drug target identification and perhaps lead to a rational therapeutic strategy to combat neurodegenerative diseases.

Original languageEnglish
Title of host publicationAutophagy of the Nervous System
Subtitle of host publicationCellular Self-Digestion in Neurons and Neurological Diseases
PublisherWorld Scientific Publishing Co.
Number of pages33
ISBN (Electronic)9789814350457
ISBN (Print)9789814350440
StatePublished - 1 Jan 2012


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