The cellular neurobiology of depression

Husseini K. Manji, Wayne C. Drevets, Dennis S. Charney

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

Original languageEnglish
Pages (from-to)541-547
Number of pages7
JournalNature Medicine
Issue number5
StatePublished - May 2001
Externally publishedYes


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