TY - JOUR
T1 - The cardiointegram
T2 - Detection of coronary artery disease in males with chest pain and a normal resting electrocardiogram
AU - Teichholz, Louis E.
AU - Steinmetz, Marilyn Y.
AU - Escher, Doris
AU - Herman, Michael V.
AU - Naimi, Shapur
AU - Mahony, Donald V.
AU - Ellestad, Myrvin H.
N1 - Funding Information:
Supported in part by a grant from The Heart Research Foundation, New York, New York The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. w 1734 solely to indicate this fact.
PY - 1986
Y1 - 1986
N2 - The cardiointegram is a non-invasive technique for the analysis of the electrical signals of the heart obtained by a transformation of the voltage vs. time format by a series of integration. This multicenter study compares the results of the cardiointegram with coronary arteriography in 140 male patients with chest pain and a normal resting electrocardiogram. The cardiointegram was determined on two resting complexes of Leads I, II, V4, V5, and V6 and called abnormal if≥four of ten complexes were abnormal, i.e., fell outside of a previously determined template of normality. The sensitivity was 73% and specificity was 78% for the diagnosis of occlusive coronary artery disease. When≥five of ten abnormal complexes were used as the cut-off for an abnormal test and "equivocal" results (four of ten abnormal, n=18) were excluded from analysis there was a sensitivity of 69% and specificity of 88%. Thirty-seven of 38 patients (97%) with an abnormal cardiointegram and a positive exercise stress test had coronary artery disease. Thus, the cardiointegram appears to be a useful non-invasive test for the detection of coronary artery disease in males with chest pain and a normal resting electrocardiogram in whom the diagnosis of coronary artery disease is being considered.
AB - The cardiointegram is a non-invasive technique for the analysis of the electrical signals of the heart obtained by a transformation of the voltage vs. time format by a series of integration. This multicenter study compares the results of the cardiointegram with coronary arteriography in 140 male patients with chest pain and a normal resting electrocardiogram. The cardiointegram was determined on two resting complexes of Leads I, II, V4, V5, and V6 and called abnormal if≥four of ten complexes were abnormal, i.e., fell outside of a previously determined template of normality. The sensitivity was 73% and specificity was 78% for the diagnosis of occlusive coronary artery disease. When≥five of ten abnormal complexes were used as the cut-off for an abnormal test and "equivocal" results (four of ten abnormal, n=18) were excluded from analysis there was a sensitivity of 69% and specificity of 88%. Thirty-seven of 38 patients (97%) with an abnormal cardiointegram and a positive exercise stress test had coronary artery disease. Thus, the cardiointegram appears to be a useful non-invasive test for the detection of coronary artery disease in males with chest pain and a normal resting electrocardiogram in whom the diagnosis of coronary artery disease is being considered.
UR - http://www.scopus.com/inward/record.url?scp=0022457780&partnerID=8YFLogxK
U2 - 10.1016/S0022-0736(86)80035-8
DO - 10.1016/S0022-0736(86)80035-8
M3 - Article
C2 - 3746151
AN - SCOPUS:0022457780
SN - 0022-0736
VL - 19
SP - 257
EP - 267
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 3
ER -