The Carcinoid Flush: Provocation by Pentagastrin and Inhibition by Somatostatin

Jürgen C. Frölich, Zachary T. Bloomgarden, John A. Oates, James E. Mcguigan, David Rabinowitz

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

THE carcinoid syndrome is characterized by episodes of flushing that appear to be secondary to the secretion of one or more substances by a tumor of enterochromaffin-cell origin.1 2 3 Flushing can be provoked pharmacologically by the administration of epinephrine,4 isoproterenol,5 ethanol,6 and calcium.7 A number of physiologic stimuli have also been reported to trigger carcinoid flushing, most notably food intake.1 Stimulated by the observation that pentagastrin evoked flushing episodes in two patients with medullary carcinoma of the thyroid (Roberts LJ, McKenna TJ, McLean GW, et al: unpublished data), we considered the possibility that gastrin could act as an endogenous trigger of.

Original languageEnglish
Pages (from-to)1055-1057
Number of pages3
JournalNew England Journal of Medicine
Volume299
Issue number19
DOIs
StatePublished - 9 Nov 1978
Externally publishedYes

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