TY - JOUR
T1 - The Carcinoid Flush
T2 - Provocation by Pentagastrin and Inhibition by Somatostatin
AU - Frölich, Jürgen C.
AU - Bloomgarden, Zachary T.
AU - Oates, John A.
AU - Mcguigan, James E.
AU - Rabinowitz, David
PY - 1978/11/9
Y1 - 1978/11/9
N2 - THE carcinoid syndrome is characterized by episodes of flushing that appear to be secondary to the secretion of one or more substances by a tumor of enterochromaffin-cell origin.1 2 3 Flushing can be provoked pharmacologically by the administration of epinephrine,4 isoproterenol,5 ethanol,6 and calcium.7 A number of physiologic stimuli have also been reported to trigger carcinoid flushing, most notably food intake.1 Stimulated by the observation that pentagastrin evoked flushing episodes in two patients with medullary carcinoma of the thyroid (Roberts LJ, McKenna TJ, McLean GW, et al: unpublished data), we considered the possibility that gastrin could act as an endogenous trigger of.
AB - THE carcinoid syndrome is characterized by episodes of flushing that appear to be secondary to the secretion of one or more substances by a tumor of enterochromaffin-cell origin.1 2 3 Flushing can be provoked pharmacologically by the administration of epinephrine,4 isoproterenol,5 ethanol,6 and calcium.7 A number of physiologic stimuli have also been reported to trigger carcinoid flushing, most notably food intake.1 Stimulated by the observation that pentagastrin evoked flushing episodes in two patients with medullary carcinoma of the thyroid (Roberts LJ, McKenna TJ, McLean GW, et al: unpublished data), we considered the possibility that gastrin could act as an endogenous trigger of.
UR - http://www.scopus.com/inward/record.url?scp=0018181361&partnerID=8YFLogxK
U2 - 10.1056/NEJM197811092991908
DO - 10.1056/NEJM197811092991908
M3 - Article
AN - SCOPUS:0018181361
SN - 0028-4793
VL - 299
SP - 1055
EP - 1057
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 19
ER -