The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients

Emily T. Martin; Ryan Tansek; Vicki Collins; Kayoko Hayakawa; Odaliz Abreu-Lanfranco; Teena Chopra; Paul R. Lephart; Jason M. Pogue; Keith S. Kaye; Dror Marchaim

doi:10.1016/j.ajic.2012.02.036

The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients

Emily T. Martin, Ryan Tansek, Vicki Collins, Kayoko Hayakawa, Odaliz Abreu-Lanfranco, Teena Chopra, Paul R. Lephart, Jason M. Pogue, Keith S. Kaye, Dror Marchaim

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Patients infected with carbapenem-resistant Enterobacteriaceae often experience delays in initiation of appropriate antimicrobial therapy and increased mortality. A score was developed to differentiate bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (16 patients) versus extended-spectrum β-lactamase-producing Enterobacteriaceae (166 patients). A score of ≥32 demonstrated high area under the curve of 0.80 (95% confidence interval: 0.68-0.92) and a negative predictive value of 97%.

Original language	English
Pages (from-to)	180-182
Number of pages	3
Journal	American Journal of Infection Control
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.ajic.2012.02.036
State	Published - Feb 2013
Externally published	Yes

Keywords

CRE
Carbapenem-resistant Enterobacteriaceae
Colistin
ESBL
Extended-spectrum β-lactamase
Klebsiella pneumoniae carbapenemase
Time to effective therapy

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10.1016/j.ajic.2012.02.036

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Martin, E. T., Tansek, R., Collins, V., Hayakawa, K., Abreu-Lanfranco, O., Chopra, T., Lephart, P. R., Pogue, J. M., Kaye, K. S., & Marchaim, D. (2013). The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients. American Journal of Infection Control, 41(2), 180-182. https://doi.org/10.1016/j.ajic.2012.02.036

@article{c6448fe8e36149c785821a1b48fd3c09,

title = "The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients",

abstract = "Patients infected with carbapenem-resistant Enterobacteriaceae often experience delays in initiation of appropriate antimicrobial therapy and increased mortality. A score was developed to differentiate bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (16 patients) versus extended-spectrum β-lactamase-producing Enterobacteriaceae (166 patients). A score of ≥32 demonstrated high area under the curve of 0.80 (95% confidence interval: 0.68-0.92) and a negative predictive value of 97%.",

keywords = "CRE, Carbapenem-resistant Enterobacteriaceae, Colistin, ESBL, Extended-spectrum β-lactamase, Klebsiella pneumoniae carbapenemase, Time to effective therapy",

author = "Martin, {Emily T.} and Ryan Tansek and Vicki Collins and Kayoko Hayakawa and Odaliz Abreu-Lanfranco and Teena Chopra and Lephart, {Paul R.} and Pogue, {Jason M.} and Kaye, {Keith S.} and Dror Marchaim",

note = "Funding Information: Supported in part by the National Institute of Health (protocol number 10-0065 to K.S.K.). ",

year = "2013",

month = feb,

doi = "10.1016/j.ajic.2012.02.036",

language = "English",

volume = "41",

pages = "180--182",

journal = "American Journal of Infection Control",

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publisher = "Mosby Inc.",

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}

Martin, ET, Tansek, R, Collins, V, Hayakawa, K, Abreu-Lanfranco, O, Chopra, T, Lephart, PR, Pogue, JM, Kaye, KS & Marchaim, D 2013, 'The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients', American Journal of Infection Control, vol. 41, no. 2, pp. 180-182. https://doi.org/10.1016/j.ajic.2012.02.036

TY - JOUR

T1 - The carbapenem-resistant Enterobacteriaceae score

T2 - A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients

AU - Martin, Emily T.

AU - Tansek, Ryan

AU - Collins, Vicki

AU - Hayakawa, Kayoko

AU - Abreu-Lanfranco, Odaliz

AU - Chopra, Teena

AU - Lephart, Paul R.

AU - Pogue, Jason M.

AU - Kaye, Keith S.

AU - Marchaim, Dror

N1 - Funding Information: Supported in part by the National Institute of Health (protocol number 10-0065 to K.S.K.).

PY - 2013/2

Y1 - 2013/2

N2 - Patients infected with carbapenem-resistant Enterobacteriaceae often experience delays in initiation of appropriate antimicrobial therapy and increased mortality. A score was developed to differentiate bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (16 patients) versus extended-spectrum β-lactamase-producing Enterobacteriaceae (166 patients). A score of ≥32 demonstrated high area under the curve of 0.80 (95% confidence interval: 0.68-0.92) and a negative predictive value of 97%.

AB - Patients infected with carbapenem-resistant Enterobacteriaceae often experience delays in initiation of appropriate antimicrobial therapy and increased mortality. A score was developed to differentiate bloodstream infections caused by carbapenem-resistant Enterobacteriaceae (16 patients) versus extended-spectrum β-lactamase-producing Enterobacteriaceae (166 patients). A score of ≥32 demonstrated high area under the curve of 0.80 (95% confidence interval: 0.68-0.92) and a negative predictive value of 97%.

KW - CRE

KW - Carbapenem-resistant Enterobacteriaceae

KW - Colistin

KW - ESBL

KW - Extended-spectrum β-lactamase

KW - Klebsiella pneumoniae carbapenemase

KW - Time to effective therapy

UR - http://www.scopus.com/inward/record.url?scp=84873077370&partnerID=8YFLogxK

U2 - 10.1016/j.ajic.2012.02.036

DO - 10.1016/j.ajic.2012.02.036

M3 - Article

C2 - 22939417

AN - SCOPUS:84873077370

VL - 41

SP - 180

EP - 182

JO - American Journal of Infection Control

JF - American Journal of Infection Control

SN - 0196-6553

IS - 2

ER -

The carbapenem-resistant Enterobacteriaceae score: A bedside score to rule out infection with carbapenem-resistant Enterobacteriaceae among hospitalized patients

Abstract

Keywords

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