The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia

Jutta Sulger; Claude Dumais-Huber; Rainer Zerfass; Fritz A. Henn; Josef B. Aldenhoff

doi:10.1016/S0006-3223(98)00218-2

The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia

Jutta Sulger, Claude Dumais-Huber, Rainer Zerfass, Fritz A. Henn, Josef B. Aldenhoff

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: A significant increase in the [Ca²⁺](i) response of single T lymphocytes to mitogenic stimulation with phytohemagglutinin is reported for 27 Alzheimer patients compared with 27 healthy gender- and age-matched control subjects, regardless of gender. Methods: The [Ca²⁺](i) signals of T lymphocytes were assessed using the Fura-2-AM method. Results: In Alzheimer's disease (AD) the reaction pattern is similar to that seen in a group of 27 young healthy control subjects who exhibited a marked [Ca²⁺](i) rise after stimulation. During normal aging the reaction pattern of T cells is significantly attenuated in comparison to that found in young subjects. In healthy control subjects differences in age-related changes in calcium homeostasis are highly significant among women, young women showing the most intense cell response. Conclusions: The elevation of [Ca²⁺](i) appears to be a prerequisite for apoptosis, which is suggested to be involved in the neuronal death occurring in AD. An increased [Ca²⁺](i) in AD is consistent with processes leading to neurodegeneration in AD.

Original language	English
Pages (from-to)	737-742
Number of pages	6
Journal	Biological Psychiatry
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/S0006-3223(98)00218-2
State	Published - 15 Mar 1999
Externally published	Yes

Keywords

Aging
Alzheimer's disease
Intracellular calcium
Mitogen phytohemagglutinin
Single human T lymphocytes

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10.1016/S0006-3223(98)00218-2

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title = "The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia",

abstract = "Background: A significant increase in the [Ca2+](i) response of single T lymphocytes to mitogenic stimulation with phytohemagglutinin is reported for 27 Alzheimer patients compared with 27 healthy gender- and age-matched control subjects, regardless of gender. Methods: The [Ca2+](i) signals of T lymphocytes were assessed using the Fura-2-AM method. Results: In Alzheimer's disease (AD) the reaction pattern is similar to that seen in a group of 27 young healthy control subjects who exhibited a marked [Ca2+](i) rise after stimulation. During normal aging the reaction pattern of T cells is significantly attenuated in comparison to that found in young subjects. In healthy control subjects differences in age-related changes in calcium homeostasis are highly significant among women, young women showing the most intense cell response. Conclusions: The elevation of [Ca2+](i) appears to be a prerequisite for apoptosis, which is suggested to be involved in the neuronal death occurring in AD. An increased [Ca2+](i) in AD is consistent with processes leading to neurodegeneration in AD.",

keywords = "Aging, Alzheimer's disease, Intracellular calcium, Mitogen phytohemagglutinin, Single human T lymphocytes",

author = "Jutta Sulger and Claude Dumais-Huber and Rainer Zerfass and Henn, {Fritz A.} and Aldenhoff, {Josef B.}",

note = "Funding Information: This work has been supported by the German Research Foundation, SFB 258/A3. ",

year = "1999",

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doi = "10.1016/S0006-3223(98)00218-2",

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T1 - The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia

AU - Sulger, Jutta

AU - Dumais-Huber, Claude

AU - Zerfass, Rainer

AU - Henn, Fritz A.

AU - Aldenhoff, Josef B.

N1 - Funding Information: This work has been supported by the German Research Foundation, SFB 258/A3.

PY - 1999/3/15

Y1 - 1999/3/15

N2 - Background: A significant increase in the [Ca2+](i) response of single T lymphocytes to mitogenic stimulation with phytohemagglutinin is reported for 27 Alzheimer patients compared with 27 healthy gender- and age-matched control subjects, regardless of gender. Methods: The [Ca2+](i) signals of T lymphocytes were assessed using the Fura-2-AM method. Results: In Alzheimer's disease (AD) the reaction pattern is similar to that seen in a group of 27 young healthy control subjects who exhibited a marked [Ca2+](i) rise after stimulation. During normal aging the reaction pattern of T cells is significantly attenuated in comparison to that found in young subjects. In healthy control subjects differences in age-related changes in calcium homeostasis are highly significant among women, young women showing the most intense cell response. Conclusions: The elevation of [Ca2+](i) appears to be a prerequisite for apoptosis, which is suggested to be involved in the neuronal death occurring in AD. An increased [Ca2+](i) in AD is consistent with processes leading to neurodegeneration in AD.

AB - Background: A significant increase in the [Ca2+](i) response of single T lymphocytes to mitogenic stimulation with phytohemagglutinin is reported for 27 Alzheimer patients compared with 27 healthy gender- and age-matched control subjects, regardless of gender. Methods: The [Ca2+](i) signals of T lymphocytes were assessed using the Fura-2-AM method. Results: In Alzheimer's disease (AD) the reaction pattern is similar to that seen in a group of 27 young healthy control subjects who exhibited a marked [Ca2+](i) rise after stimulation. During normal aging the reaction pattern of T cells is significantly attenuated in comparison to that found in young subjects. In healthy control subjects differences in age-related changes in calcium homeostasis are highly significant among women, young women showing the most intense cell response. Conclusions: The elevation of [Ca2+](i) appears to be a prerequisite for apoptosis, which is suggested to be involved in the neuronal death occurring in AD. An increased [Ca2+](i) in AD is consistent with processes leading to neurodegeneration in AD.

KW - Aging

KW - Alzheimer's disease

KW - Intracellular calcium

KW - Mitogen phytohemagglutinin

KW - Single human T lymphocytes

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JO - Biological Psychiatry

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ER -

The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia

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