The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells

Gaëtan Barbet, Marie Demion, Ivan C. Moura, Nicolas Serafini, Thibaut Léger, François Vrtovsnik, Renato C. Monteiro, Romain Guinamard, Jean Pierre Kinet, Pierre Launay

Research output: Contribution to journalArticlepeer-review

164 Scopus citations

Abstract

Dendritic cell (DC) maturation and migration are events critical for the initiation of immune responses. After encountering pathogens, DCs upregulate the expression of costimulatory molecules and subsequently migrate to secondary lymphoid organs. Calcium (Ca2+) entry governs the functions of many hematopoietic cell types, but the role of Ca2+ entry in DC biology remains unclear. Here we report that the Ca2+-activated nonselective cation channel TRPM4 was expressed in and controlled the Ca2+ homeostasis of mouse DCs. The absence of TRPM4, which elicited Ca2+ overload, did not influence DC maturation but did considerably impair chemokine-dependent DC migration. Our results establish TRPM4-regulated Ca2+ homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated.

Original languageEnglish
Pages (from-to)1148-1156
Number of pages9
JournalNature Immunology
Volume9
Issue number10
DOIs
StatePublished - 2008
Externally publishedYes

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