The biomechanics and prevention of vein graft failure in coronary revascularization

Elbert E. Heng; Hanjay Wang; Oluwatomisin Obafemi; Alison Marsden; Y. Joseph Woo; Jack H. Boyd

doi:10.20517/2574-1209.2023.97

The biomechanics and prevention of vein graft failure in coronary revascularization

Elbert E. Heng, Hanjay Wang, Oluwatomisin Obafemi, Alison Marsden, Y. Joseph Woo, Jack H. Boyd

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardial revascularization. This review will provide a comprehensive overview of the biological mechanisms of vein graft failure, including compensatory endothelial proliferation, extracellular matrix deposition, and adventitial disruption. We will discuss historical and emerging strategies for vein graft failure prevention with a focus on the role of mechanical vein graft support using external stenting. Finally, we will highlight the results of preclinical and human trials and discuss future directions for investigation.

Original language	English
Article number	31
Journal	Vessel Plus
Volume	7
DOIs	https://doi.org/10.20517/2574-1209.2023.97
State	Published - 2023
Externally published	Yes

Keywords

Coronary artery bypass grafting
external stenting
neointimal hyperplasia
saphenous vein
vein graft failure
vein graft remodeling

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title = "The biomechanics and prevention of vein graft failure in coronary revascularization",

abstract = "Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardial revascularization. This review will provide a comprehensive overview of the biological mechanisms of vein graft failure, including compensatory endothelial proliferation, extracellular matrix deposition, and adventitial disruption. We will discuss historical and emerging strategies for vein graft failure prevention with a focus on the role of mechanical vein graft support using external stenting. Finally, we will highlight the results of preclinical and human trials and discuss future directions for investigation.",

keywords = "Coronary artery bypass grafting, external stenting, neointimal hyperplasia, saphenous vein, vein graft failure, vein graft remodeling",

author = "Heng, {Elbert E.} and Hanjay Wang and Oluwatomisin Obafemi and Alison Marsden and Woo, {Y. Joseph} and Boyd, {Jack H.}",

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year = "2023",

doi = "10.20517/2574-1209.2023.97",

language = "English",

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journal = "Vessel Plus",

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T1 - The biomechanics and prevention of vein graft failure in coronary revascularization

AU - Heng, Elbert E.

AU - Wang, Hanjay

AU - Obafemi, Oluwatomisin

AU - Marsden, Alison

AU - Woo, Y. Joseph

AU - Boyd, Jack H.

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2023

Y1 - 2023

N2 - Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardial revascularization. This review will provide a comprehensive overview of the biological mechanisms of vein graft failure, including compensatory endothelial proliferation, extracellular matrix deposition, and adventitial disruption. We will discuss historical and emerging strategies for vein graft failure prevention with a focus on the role of mechanical vein graft support using external stenting. Finally, we will highlight the results of preclinical and human trials and discuss future directions for investigation.

AB - Saphenous vein grafts (SVGs) are the most widely used conduit in coronary artery bypass grafting (CABG) surgery; however, SVG failures due to neointimal hyperplasia present a significant long-term limitation to the effectiveness of myocardial revascularization. This review will provide a comprehensive overview of the biological mechanisms of vein graft failure, including compensatory endothelial proliferation, extracellular matrix deposition, and adventitial disruption. We will discuss historical and emerging strategies for vein graft failure prevention with a focus on the role of mechanical vein graft support using external stenting. Finally, we will highlight the results of preclinical and human trials and discuss future directions for investigation.

KW - Coronary artery bypass grafting

KW - external stenting

KW - neointimal hyperplasia

KW - saphenous vein

KW - vein graft failure

KW - vein graft remodeling

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U2 - 10.20517/2574-1209.2023.97

DO - 10.20517/2574-1209.2023.97

M3 - Review article

AN - SCOPUS:85201514523

SN - 2574-1209

VL - 7

JO - Vessel Plus

JF - Vessel Plus

M1 - 31

ER -

The biomechanics and prevention of vein graft failure in coronary revascularization

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Keywords

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