TY - JOUR
T1 - The biology of stem cell factor, a new hematopietic growth factor involved in stem cell regulation
AU - Galli, Maria Cristina
AU - Giardina, Patricia Jane V.
AU - Migliaccio, Anna Rita
AU - Migliaccio, Giovanni
PY - 1993/12
Y1 - 1993/12
N2 - Recently, a new hematopoietic growth factor, stem cell factor, the ligand for the c-kit-proto-oncogene, has been cloned. The gene for this factor or for its receptor are deleted in two well know series of mice mutants which display pleiotropic stem cell defects. Therefore, this factor supposedly plays an important role in stem cell biology. This paper reviews some of the elegant genetic work which led to the discovery of the factor and of its receptor, the biological effects that this factor exerts in the hematopoietic system in normal individuals and in patients with Diamond-Blackfan anemia and speculates on some of its potential clinical applications.
AB - Recently, a new hematopoietic growth factor, stem cell factor, the ligand for the c-kit-proto-oncogene, has been cloned. The gene for this factor or for its receptor are deleted in two well know series of mice mutants which display pleiotropic stem cell defects. Therefore, this factor supposedly plays an important role in stem cell biology. This paper reviews some of the elegant genetic work which led to the discovery of the factor and of its receptor, the biological effects that this factor exerts in the hematopoietic system in normal individuals and in patients with Diamond-Blackfan anemia and speculates on some of its potential clinical applications.
KW - C-kit
KW - Diamond-Blackfan Anemia
KW - Hematopoiesis
KW - Stem cell factor
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=0027342525&partnerID=8YFLogxK
U2 - 10.1007/BF02592286
DO - 10.1007/BF02592286
M3 - Review article
C2 - 7686057
AN - SCOPUS:0027342525
SN - 0940-5437
VL - 23
SP - 70
EP - 77
JO - International Journal of Clinical & Laboratory Research
JF - International Journal of Clinical & Laboratory Research
IS - 1-4
ER -