@article{52753081e0cb4ffeb6a0763060c04670,
title = "The biology of influenza viruses",
abstract = "The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts.",
keywords = "Antigenic drift, Antigenic shift, Influenza virus, RNA viruses",
author = "Bouvier, {Nicole M.} and Peter Palese",
note = "Funding Information: Work performed in the laboratory of the authors was partially supported by the NIH Center for Investigating Viral Immunity and Antagonism (1 UC19 AI062623-023), the NIH Center for Research on Influenza Pathogenesis (HHSN266200700010C), and NIH grants UO1 AI070469 and UO1 AI1074539. NMB is supported by a Ruth L. Kirschstein National Research Service Award for Physician-Scientist Research Training in the Pathogenesis of Viral Diseases (NIH grant T32 AI007623; P.I. Mary E. Klotman, M.D.).",
year = "2008",
month = sep,
day = "12",
doi = "10.1016/j.vaccine.2008.07.039",
language = "English",
volume = "26",
pages = "D49--D53",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier Ltd.",
number = "SUPPL. 4",
}