The biology of influenza viruses

Nicole M. Bouvier, Peter Palese

Research output: Contribution to journalArticlepeer-review

785 Scopus citations

Abstract

The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts.

Original languageEnglish
Pages (from-to)D49-D53
JournalVaccine
Volume26
Issue numberSUPPL. 4
DOIs
StatePublished - 12 Sep 2008

Keywords

  • Antigenic drift
  • Antigenic shift
  • Influenza virus
  • RNA viruses

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