The biologic significance of the aldosterone concentration in saliva

Robert McVie, Lenore S. Levine, Maria I. New

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Salivary aldosterone measurements can be used to study aldosterone secretion and metabolism noninvasively. Salvia and plasma aldosterone concentration were highly correlated during all periods of study; during adrenocorticotrophic hormone (ACTH) administration, a relatively greater amount of aldosterone appeared in saliva; during dexamethasone administration, a relatively smaller amount of aldosterone appeared in saliva. As plasma cortisol increased with ACTH administration there was an increased relative amount of aldosterone in saliva. DOC (11-deoxycorticosterone) was found in saliva only during ACTH administration. Corticosterone was identified during baseline periods. Salivary aldosterone concentrations were independent of flow. The data indicate that saliva is an accessible bodily fluid which may be used to monitor the changes in nonprotein bound plasma steroid hormone concentration in children.

Original languageEnglish
Pages (from-to)755-759
Number of pages5
JournalPediatric Research
Issue number6
StatePublished - Jun 1979
Externally publishedYes


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